Iron porphyrin-catalyzed olefination of ketenes with diazoacetate for the enantioselective synthesis of allenes

被引：145

作者：

Li, Chuan-Ying

Wang, Xiao-Bing

Sun, Xiu-Li

Tang, Yong

Zheng, Jun-Cheng

Xu, Zheng-Hu

Zhou, Yong-Gui

Dai, Li-Xin

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organomet Chem, Shanghai 200032, Peoples R China

[2] Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2007年 / 129卷 / 06期

关键词：

D O I：

10.1021/ja068642v

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In the presence of Ph3P and catalytic Fe(TCP) Cl, ketenes could react with EDA to give allenes in high yields under neutral conditions for the first time. By employing chiral phosphine instead of PPh3, allenes could be synthesized with high enantioselectivity (93-98% ee) in good yields.

引用

页码：1494 / +

页数：3

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