Effects of Insulin Therapy with Continuous Subcutaneous Insulin Infusion (CSII) in Diabetic Patients: Comparison with Multi-daily Insulin Injections Therapy (MDI)

被引：10

作者：

Derosa, Giuseppe ^{[1
]}

Maffioli, Pamela ^{[1
]}

D'Angelo, Angela ^{[1
]}

Salvadeo, Sibilla A. T. ^{[1
]}

Ferrari, Ilaria ^{[1
]}

Fogari, Elena ^{[1
]}

Mereu, Roberto ^{[1
]}

Gravina, Alessia ^{[1
]}

Palumbo, Ilaria ^{[1
]}

Randazzo, Sabrina ^{[1
]}

Cicero, Arrigo F. G. ^{[2
]}

机构：

[1] Univ Pavia, Dept Internal Med & Therapeut, I-27100 Pavia, Italy

[2] Univ Bologna, Dept Internal Med Aging & Kidney Dis, G Descovich Atherosclerosis Study Ctr, Bologna, Italy

来源：

ENDOCRINE JOURNAL | 2009年 / 56卷 / 04期

关键词：

CSII; MDI; Insulin therapy; Diabetic patients; GLYCEMIC CONTROL; PUMP THERAPY; METABOLIC-CONTROL; BASAL INSULIN; IMPROVEMENT; GLARGINE; MELLITUS; CHILDREN; RISK;

D O I：

10.1507/endocrj.K08E-330

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We compared the effects of continuous subcutaneous insulin infusion (CSII) and multi-daily insulin injections therapy (MDI) on glicemic control and on lipid profile in type 1 and type 2 diabetic patients. We divided the patients in two groups: in the first one (n=32) CSII was administered, in the second one (n=32) MDI was administered. HbA(1c) value was lower after 3, 6, 9, and 12 months with CSII compared to MDI. Fasting plasma glucose (FPG) value was lower with CSII after 3, 6, and 12 months compared to MDI. Post-prandial glucose (PPG) value was lower in the group with CSII after 3, 6, 9, and 12 months compared to MDI. A significant TC decrease was observed in the group treated with CSII at 9, and 12 months while a significant TC increase was observed with MDI at 6, and 12 months. A significant LDL-C decrease was obtained with CSII after 9, and 12 months while no significant changes were observed with MDI. A significant HDL-C increase was observed with CSII after 12 months. A significant Tg decrease was observed with CSII after 12 months while a significant Tg increase was observed with MDI at 6, and at 12 months. CSII therapy allows a faster and better achievement of the therapeutic target and also gives an improvement of the lipid profile.

引用

页码：571 / 578

页数：8

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