Effect of anti-digoxin antiserum on endoxin and membrane ATPase activity in hypoxia-reoxygenation induced myocardial injury

被引：0

作者：

Ke, YS ^{[1
]}

Liu, ZF ^{[1
]}

Yang, H ^{[1
]}

Yang, T ^{[1
]}

Huang, JS ^{[1
]}

Rui, SB ^{[1
]}

Cheng, GH ^{[1
]}

Wang, YX ^{[1
]}

机构：

[1] Wannan Med Coll, Yijishan Hosp, Wuhu 241001, Peoples R China

来源：

ACTA PHARMACOLOGICA SINICA | 2000年 / 21卷 / 04期

关键词：

myocardium; anoxia; endoxin; Na+-K+-exchanging ATPase; Ca2+-transporting ATPase; digoxin; immune sera;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

AIM: To evaluate the protective effect of anti-digoxin antiserum on hypoxia-reoxygenation induced injured myocardium and its mechanism. METHODS: Anti-digoxin antiserum of different concentrations was used, its effect on endoxin and ATPase activity in cell membrane in hypoxia-reoxygenation myocardium model was observed. RESULTS: The level of endoxin was remarkably higher, ATPase activities in cell membrane were remarkably lower in hypoxic group and hypoxia-reoxygenation injury group than those of normal group; anti-digoxin antiserum could resume ATPase activity in a concentration-dependent manner. CONCLUSION: Rise of endoxin was the molecular biological basis of myocardial damage during myocardial hypoxia-reoxygenation. Anti-digoxin antiserum had lessened myocardial injury and had a protective effect on hypoxia-reoxygenation myocardium by antagonizing effect of endoxin.

引用

页码：345 / 347

页数：3

共 7 条

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