Pharmacologic ascorbate concentrations selectively kill cancer cells:: Ascorbic acid as a prodrug for ascorbate radical or H2O2 delivery to tissues

被引：0
|
作者：
Chen, Qi
Lee, Je-Hyuk
Zhang, Liqun
Sun, Andrew
Krishna, Murali C.
Espey, Michael G.
Pooput, Chaya
Kirk, Kenneth
Choyke, Peter
Buettner, Garry R.
Shacter, Emily
Levine, Mark
机构：
[1] NIDDKD, NIH, Bethesda, MD 20892 USA
[2] NCI, NIH, Bethesda, MD 20892 USA
[3] Univ Iowa, Coll Med, Iowa City, IA USA
[4] US FDA, Ctr Biol Evaluat & Res, Rockville, MD 20857 USA
来源：
JOURNAL OF NUTRITION | 2007年 / 137卷 / 01期
关键词：
D O I：
暂无
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
引用
收藏
页码：293S / 293S
页数：1
相关论文
共 50 条
  • [1] Intravenous ascorbic acid as a pro-drug for ascorbate radical and H2O2 delivery to tissues:: Implications in cancer treatment
    Chen, Qi
    Lee, Je-Hyuk
    Sun, Andrew
    Zhang, Liqun
    Espey, Michael
    Krishna, Murali
    Pooput, Chaya
    Kirk, Kenneth
    Choyke, Peter
    Buettner, Garry
    Shacter, Emily
    Levine, Mark
    FREE RADICAL BIOLOGY AND MEDICINE, 2006, 41 : S64 - S64
  • [2] Pharmacologic ascorbic acid concentrations selectively kill cancer cells: Action as a pro-drug to deliver hydrogen peroxide to tissues
    Chen, Q
    Espey, MG
    Krishna, MC
    Mitchell, JB
    Corpe, CP
    Buettner, GR
    Shacter, E
    Levine, M
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (38) : 13604 - 13609
  • [3] H2O2-mediated Cytotoxicity of Pharmacologic Ascorbate Concentrations to Neuroblastoma Cells: Potential Role of Lactate and Ferritin
    Deubzer, Beate
    Mayer, Florian
    Kuci, Zyrafete
    Niewisch, Marena
    Merkel, Gisela
    Handgretinger, Rupert
    Bruchelt, Gernot
    CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2010, 25 (06) : 767 - 774
  • [4] Ascorbate and H2O2 induced oxidative DNA damage in Jurkat cells
    Riviere, Johann
    Ravanat, Jean-Luc
    Wagner, J. Richard
    FREE RADICAL BIOLOGY AND MEDICINE, 2006, 40 (12) : 2071 - 2079
  • [5] ASCORBATE PEROXIDASE EXPRESSION IN TOBACCO IS REGULATED BY H2O2
    SENGUPTA, A
    WEBB, RP
    HOLADAY, AS
    ALLEN, RD
    JOURNAL OF CELLULAR BIOCHEMISTRY, 1994, : 95 - 95
  • [6] Tumor cells have decreased ability to metabolize H2O2: Implications for pharmacological ascorbate in cancer therapy
    Doskey, Claire M.
    Buranasudja, Visarut
    Wagner, Brett A.
    Wilkes, Justin G.
    Du, Juan
    Cullen, Joseph J.
    Buettner, Garry R.
    REDOX BIOLOGY, 2016, 10 : 274 - 284
  • [7] Ascorbate modulation of H2O2 and camptothecin-induced cell death in Jurkat cells
    Sané, AT
    Cantin, AM
    Paquette, B
    Wagner, JR
    CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2004, 54 (04) : 315 - 321
  • [8] Ascorbate modulation of H2O2 and camptothecin-induced cell death in Jurkat cells
    Alain-Théophile Sané
    André M. Cantin
    Benoit Paquette
    J. Richard Wagner
    Cancer Chemotherapy and Pharmacology, 2004, 54 : 315 - 321
  • [9] Generation of H2O2 by Ascorbate Auto-oxidation: Possible Implications for Cancer Therapy
    Michels, Alexander J.
    Dickinson, Bryan C.
    Chang, Christopher J.
    Frei, Balz
    FREE RADICAL BIOLOGY AND MEDICINE, 2010, 49 : S190 - S190
  • [10] Manganoporphyrin MnTMPyP Enhances Ascorbate-Induced Cytotoxicity in Pancreatic Cancer Cells Via Generation of H2O2
    Rawal, Malvika
    Schroeder, Samuel R.
    Du, Juan
    Wagner, Brett A.
    Buettner, Garry R.
    Cullen, Joseph J.
    FREE RADICAL BIOLOGY AND MEDICINE, 2011, 51 : S128 - S128
12345