Vitamin D Deficiency Attenuates Acute Alcohol-Induced Hepatic Lipid Accumulation in Mice

被引:6
作者
Hu, Chun-Qiu [1 ,2 ]
Xu, Meng [2 ]
Yang, Bing-Bing [3 ]
Liu, Xiao-Jing [4 ]
Bo, Qing-Li [1 ,2 ]
Zhang, Cheng [1 ]
Xu, De-Xiang [1 ]
机构
[1] Anhui Med Univ, Dept Toxicol, Sch Publ Hlth, Hefei 230032, Anhui, Peoples R China
[2] Anhui Med Univ, Sch Publ Hlth, Dept Nutr & Hyg, Hefei 230032, Anhui, Peoples R China
[3] Anhui Med Univ, Dept Gastroenterol, Affiliated Hosp 4, Hefei 230012, Anhui, Peoples R China
[4] Anhui Med Univ, Affiliated Hosp 1, Dept Paediat, Hefei 230022, Anhui, Peoples R China
基金
中国国家自然科学基金;
关键词
Alcohol fatty liver; Lipid accumulation; Lipid metabolism; Vitamin D deficiency; LIVER-DISEASE PATHOGENESIS; FATTY-ACID SYNTHESIS; D-RECEPTOR; PPAR-GAMMA; GENE-EXPRESSION; BETA-OXIDATION; BINGE ETHANOL; STEATOSIS; OBESITY; DYSFUNCTION;
D O I
10.1002/lipd.12188
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Vitamin D deficiency has been frequently reported in chronic liver disease. However, its influence on hepatic lipid accumulation in alcoholic liver disease remains unclear. The present study investigated the effects of vitamin D deficiency on acute alcohol-induced hepatic lipid metabolism in mice. Mice were fed with vitamin D deficient diet, in which vitamin D was depleted for 12 weeks to establish an animal model of vitamin D deficiency. Some mice were administered a single gavage of alcohol (4 g/kg bodyweight) before they were euthanized. Results show that feeding mice with vitamin D deficient diet did not induce hepatic lipid accumulation. In contrast, vitamin D deficiency markedly reduced alcohol-induced triacylglycerol (TAG) content and prevented hepatic lipid accumulation. Moreover, vitamin D deficiency significantly attenuated alcohol-induced sterol-regulated element-binding protein (SREBP)-1c activation, which regulates genes for hepatic fatty acid (FA) and TAG synthesis, and the expression of its target genes fatty acid synthase (Fasn) and acetyl-coenzyme- A carboxylase (Acc). In addition, vitamin D deficiency alleviated alcohol-induced downregulation of hepatic nuclear peroxisome proliferator-activated receptor (PPAR)alpha, which governs FA transport and beta-oxidation, and the expression of Carnitine palmitoyltransferase (Cpt)-1 alpha, cytochrome P450, family 4, subfamily a, polypeptide (Cyp4a)10, and Cyp4a14, which are key enzymes for hepatic fatty acids beta-oxidation and omega-oxidation. Taken together, these results suggest that vitamin D deficiency is not a direct risk factor for hepatic lipid accumulation. Vitamin D deficiency alleviates acute alcohol-induced hepatic lipid accumulation through inhibiting hepatic de novo fatty acid syntheses and promoting fatty acid beta-oxidation and omega-oxidation.
引用
收藏
页码:651 / 663
页数:13
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