Diabetes mellitus as a risk factor for gastrointestinal cancer among American veterans

被引:56
作者
Jamal, M. Mazen [1 ,2 ]
Yoon, Eugene J. [1 ,2 ]
Vega, Kenneth J. [3 ]
Hashemzadeh, Mehrtash [1 ]
Chang, Kenneth J. [2 ]
机构
[1] Vet Affairs Med Ctr, Div Gastroenterol, Long Beach, CA 90822 USA
[2] Univ Calif, Irvine Med Ctr, Dept Internal Med, Coll Med,Div Gastroenterol, Orange, CA 92868 USA
[3] Univ Florida, Div Gastroenterol, Jacksonville, FL 32207 USA
关键词
Diabetes mellitus; Pancreatic neoplasms; Adenocarcinoma; Gallbladder neoplasms; PANCREATIC-CANCER; HEPATOCELLULAR-CARCINOMA; COHORT; GALLBLADDER; PREVALENCE;
D O I
10.3748/wjg.15.5274
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
AIM: To assess the risk of biliary and pancreatic cancers in a large cohort of patients with type 2 diabetes mellitus (DM). METHODS: Eligibility for this study included patients with type 2 DM (ICD-9 code 250.0) who were discharged from Department of Veteran Affairs hospitals between 1990 and 2000. Non-matched control patients without DM were selected from the same patient treatment files during the same period. Demographic information included age, sex and race. Secondary diagnoses included known risk factors based on their ICD-9 codes. By multivariate logistic regression, the occurrence of biliary and pancreatic cancer was compared between case subjects with DM and controls without DM. RESULTS: A total of 1172496 case and control subjects were analyzed. The mean age for study and control subjects was 65.8 +/- 11.3 and 64.8 +/- 12.6 years, respectively. The frequency of pancreatic cancer in subjects with DM was increased (0.9%) in comparison to control subjects (0.3%) with an OR of 3.22 (95% CI: 3.03-3.42). The incidence of gallbladder and extrahepatic biliary cancers was increased by twofold in diabetic patients when compared to controls. The OR and 95% CI were 2.20 (1.56-3.00) and 2.10 (1.61-2.53), respectively. CONCLUSION: Our study demonstrated that patients with DM have a threefold increased risk for developing pancreatic cancer and a twofold risk for developing biliary cancer. (C) 2009 The WIG Press and Baishideng. All rights reserved.
引用
收藏
页码:5274 / 5278
页数:5
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