PREDICTORS OF OUTCOME FOR ADVANCED-STAGE SUPRAGLOTTIC LARYNGEAL CANCER

被引：30

作者：

Ganly, Ian ^{[1
]}

Patel, Snehal G. ^{[1
]}

Matsuo, Jeanette ^{[1
]}

Singh, Bhuvanesh ^{[1
]}

Kraus, Dennis H. ^{[1
]}

Boyle, Jay ^{[1
]}

Wong, Richard J. ^{[1
]}

Lee, Nancy ^{[2
]}

Pfister, David G. ^{[3
]}

Shaha, Ashok R. ^{[1
]}

Shah, Jatin P. ^{[1
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Dept Surg, Head & Neck Serv, New York, NY 10021 USA

[2] Mem Sloan Kettering Canc Ctr, Dept Radiat Oncol, New York, NY 10021 USA

[3] Mem Sloan Kettering Canc Ctr, Dept Med Oncol, New York, NY 10021 USA

来源：

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2009年 / 31卷 / 11期

关键词：

supraglottic; larynx cancer; outcome; SQUAMOUS-CELL CARCINOMA; RADIATION-THERAPY; CONCURRENT CHEMOTHERAPY; ORGAN PRESERVATION; RANDOMIZED-TRIAL; ADVANCED HEAD; NECK-CANCER; RADIOTHERAPY; IRRADIATION; SURGERY;

D O I：

10.1002/hed.21113

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Background. The objective of this study was to report our experience in the management of patients with advanced-stage supraglottic laryngeal carcinoma and to identify factors predictive of outcome. Methods. In total, 181 patients with advanced-stage supraglottic laryngeal carcinoma were treated at Memorial Sloan-Kettering Cancer Center between 1984 and 1998. Sixty-nine (38%) patients were treated by surgery postoperative radiotherapy (SRT), 93 (52%) by chemoradiotherapy (CTRT), and 19 (10%) by radiotherapy alone (RT). Survival outcomes were calculated using the Kaplan-Meier method. Predictors of outcome were identified using multivariate analysis. Results. The-5 year overall survival (OS) and disease-specific survival (DSS) were 53% and 71%, respectively. Patients treated with SRT and CTRT had comparable outcomes. The main independent predictors of OS and DSS were age greater than 60 years and stage of the neck at presentation. Conclusion. Regardless of index treatment, age over 60 years and clinical stage of the neck at presentation were the main independent predictors of OS and DSS. (C) 2009 Wiley Periodicals, Inc. Head Neck 31: 1489-1495, 2009

引用

页码：1489 / 1495

页数：7

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