Function of Deptor and its roles in hematological malignancies

被引：7

作者：

Morales-Martinez, Mario ^{[1
]}

Lichtenstein, Alan ^{[2
]}

Vega, Mario I. ^{[1
,2
]}

机构：

[1] UIMEO, Siglo Natl Med Ctr 21, Mol Signal Pathway Canc Lab, Oncol Hosp,IMSS, Mexico City, DF, Mexico

[2] Univ Calif Los Angeles, Jonsson Comprehens Canc Ctr, Greater Los Angeles VA Healthcare Ctr, Dept Med,Hematol Oncol Div,Med Ctr, Los Angeles, CA 90024 USA

来源：

AGING-US | 2021年 / 13卷 / 01期

关键词：

Deptor; Multiple Myeloma; leukemia; Non-Hodgkin Lymphoma; hematological malignances; B-CELL LYMPHOMA; GENE-EXPRESSION PROFILES; YIN YANG 1; ACUTE LYMPHOBLASTIC-LEUKEMIA; AFFECTING BAND 3Q27; MULTIPLE-MYELOMA; MICRORNA EXPRESSION; PREDICTS SURVIVAL; HODGKIN LYMPHOMA; GERMINAL CENTER;

D O I：

10.18632/aging.202462

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Deptor is a protein that interacts with mTOR and that belongs to the mTORC1 and mTORC2 complexes. Deptor is capable of inhibiting the kinase activity of mTOR. It is well known that the mTOR pathway is involved in various signaling pathways that are involved with various biological processes such as cell growth, apoptosis, autophagy, and the ER stress response. Therefore, Deptor, being a natural inhibitor of mTOR, has become very important in its study. Because of this, it is important to research its role regarding the development and progression of human malignancies, especially in hematologic malignancies. Due to its variation in expression in cancer, it has been suggested that Deptor can act as an oncogene or tumor suppressor depending on the cellular or tissue context. This review discusses recent advances in its transcriptional and post-transcriptional regulation of Deptor. As well as the advances regarding the activities of Deptor in hematological malignancies, its possible role as a biomarker, and its possible clinical relevance in these malignancies.

引用

页码：1528 / 1564

页数：37

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