Cobalt-Catalyzed Diastereoselective Difluoroalkylation/Giese Addition Domino Reactions

被引：42
|
作者：
Han, Shengnan [1 ]
Liu, Shaodong [1 ]
Liu, Lei [1 ]
Ackermann, Lutz [2 ]
Li, Jie [1 ]
机构：
[1] Jiangnan Univ, Sch Pharmaceut Sci, Lihu Rd 1800, Wuxi 214122, Jiangsu, Peoples R China
[2] Georg August Univ Gottingen, Inst Organ & Biomol Chem, Tammannstr 2, D-37077 Gottingen, Germany
来源：
ORGANIC LETTERS | 2019年 / 21卷 / 14期
基金：
中国国家自然科学基金;
关键词：
RAUHUT-CURRIER REACTION; ENANTIOSELECTIVE DESYMMETRIZATION; ARYLATIVE CYCLIZATION; CYCLOHEXADIENONES; ACCESS; FLUORINE; MONO; DIFLUOROMETHYLATION; TRANSFORMATIONS; DEAROMATIZATION;
D O I：
10.1021/acs.orglett.9b01400
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient cobalt-catalyzed difluoroalkylation/Giese radical conjugate cyclization manifold with various alkyne-tethered cyclohexadienones and halogenated fluorinating reagents was accomplished under remarkable mild reaction conditions, thus providing an expedient route to valuable fluorinated chromens. The utility of this transformation was demonstrated by high site selectivity as well as chemo- and diastereoselectivity, broad substrate scope, excellent functional group tolerance, and facile late-stage modification.
引用
收藏
页码：5387 / 5391
页数：5
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