Identification of nine new HLA class I alleles in volunteers from the Singapore stem cell donor registries

被引：10

作者：

Tang, T. F.

Hou, L.

Tu, B.

Hwang, W. Y. K.

Yeoh, A. E. J.

Ng, J.

Hurley, C. K.

机构：

[1] Georgetown Univ, Med Ctr, Dept Oncol, Washington, DC 20057 USA

[2] Georgetown Univ, Med Ctr, Dept Pediat, Washington, DC 20007 USA

[3] Singapore Bone Marrow Donor Program, Singapore, Singapore

[4] Singapore Cord Blood Bank, Singapore, Singapore

来源：

TISSUE ANTIGENS | 2006年 / 68卷 / 06期

关键词：

class I; HLA; new allele; stem cell registry;

D O I：

10.1111/j.1399-0039.2006.00707.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Based on unusual probe hybridization patterns, two human leukocyte antigen (HLA)-A, five HLA-B, and two HLA-C alleles (A*240208, A*3211Q; B*1822, B*3938Q, B*4606, B*4607N, B*5139; Cw*0321, Cw*0734) were identified in individuals from the Singapore Bone Marrow Donor Program and Singapore Cord Blood Bank. Eight of the nine alleles encode amino acid substitutions altering the antigen-binding region including three alleles with changes altering a cysteine at codon 164 (A*3211Q, B*3938Q, B*4607N). This substitution either eliminates a key disulfide bond or results in a stop codon, both likely affecting the expression of the HLA molecules. Only one allele (A*240208) carries a synonymous substitution.

引用

页码：518 / 520

页数：3