Low Normal Cerebrospinal Fluid Aβ42 Levels Predict Clinical Progression in Nondemented Subjects

被引：20

作者：

Tijms, Betty M. ^{[1
,2
]}

Bertens, Daniela ^{[1
,2
]}

Slot, Rosalinde E. ^{[1
,2
]}

Gouw, Alida A. ^{[1
,2
,3
]}

Teunissen, Charlotte E. ^{[4
]}

Scheltens, Philip ^{[1
,2
]}

van der Flier, Wiesje M. ^{[1
,2
,5
]}

Visser, Pieter Jelle ^{[1
,2
,6
]}

机构：

[1] Vrije Univ Amsterdam, Med Ctr, Amsterdam Neurosci, Alzheimer Ctr, POB 7057, NL-1007 MB Amsterdam, Netherlands

[2] Vrije Univ Amsterdam, Med Ctr, Amsterdam Neurosci, Dept Neurol, POB 7057, NL-1007 MB Amsterdam, Netherlands

[3] Vrije Univ Amsterdam, Med Ctr, Amsterdam Neurosci, Dept Clin Neurophysiol,MEG Ctr, Amsterdam, Netherlands

[4] Vrije Univ Amsterdam, Med Ctr, Amsterdam Neurosci, Neurochem Lab & Biobank,Dept Clin Chem, Amsterdam, Netherlands

[5] Vrije Univ Amsterdam, Med Ctr, Amsterdam Neurosci, Dept Epidemiol & Biostat, Amsterdam, Netherlands

[6] Maastricht Univ, Sch Mental Hlth & Neurosci, Dept Psychiat & Neuropsychol, Maastricht, Netherlands

来源：

ANNALS OF NEUROLOGY | 2017年 / 81卷 / 05期

关键词：

MILD COGNITIVE IMPAIRMENT; ALZHEIMERS ASSOCIATION WORKGROUPS; BETA-AMYLOID; 42; DIAGNOSTIC GUIDELINES; NATIONAL INSTITUTE; DISEASE; BIOMARKERS; DEMENTIA; TAU; RECOMMENDATIONS;

D O I：

10.1002/ana.24921

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We studied whether continuous lower normal cerebrospinal fluid (CSF) amyloid beta 1-42 (>= 640pg/ml) levels were related with rate of clinical progression in a sample of 393 nondemented memory clinic patients. Lower normal levels were associated with faster clinical progression, and this depended on baseline cognitive status (subjective cognitive decline: hazard ratio [HR] = 0.57, p < 0.05; mild cognitive impairment: HR = 0.19, p < .01), indicating that normal CSF amyloid levels do not exclude incident Alzheimer disease. These findings suggest that research on preclinical markers for Alzheimer disease should take the continuum of CSF amyloid beta 1-42 levels within the normal range into account.

引用

页码：749 / 753

页数：5

共 21 条

[1] The diagnosis of mild cognitive impairment due to Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease [J].

Albert, Marilyn S. ;

DeKosky, Steven T. ;

Dickson, Dennis ;

Dubois, Bruno ;

Feldman, Howard H. ;

Fox, Nick C. ;

Gamst, Anthony ;

Holtzman, David M. ;

Jagust, William J. ;

Petersen, Ronald C. ;

Snyder, Peter J. ;

Carrillo, Maria C. ;

Thies, Bill ;

Phelps, Creighton H. .

ALZHEIMERS & DEMENTIA, 2011, 7 (03) :270-279

[2] Cerebrospinal Fluid Levels of β-Amyloid 1-42, but Not of Tau, Are Fully Changed Already 5 to 10 Years Before the Onset of Alzheimer Dementia [J].

Buchhave, Peder ;

Minthon, Lennart ;

Zetterberg, Henrik ;

Wallin, Asa K. ;

Blennow, Kaj ;

Hansson, Oskar .

ARCHIVES OF GENERAL PSYCHIATRY, 2012, 69 (01) :98-106

[3] Correcting for the Absence of a Gold Standard Improves Diagnostic Accuracy of Biomarkers in Alzheimer's Disease [J].

Coart, Els ;

Barrado, Leandro Garcia ;

Duits, Flora H. ;

Scheltens, Philip ;

van der Flier, Wiesje M. ;

Teunissen, Charlotte E. ;

van der Vies, Saskia M. ;

Burzykowski, Tomasz .

JOURNAL OF ALZHEIMERS DISEASE, 2015, 46 (04) :889-899

[4] ALZHEIMERS-DISEASE - THE AMYLOID CASCADE HYPOTHESIS [J].

HARDY, JA ;

HIGGINS, GA .

SCIENCE, 1992, 256 (5054) :184-185

[5] Accelerating rates of cognitive decline and imaging markers associated with -amyloid pathology [J].

Insel, Philip S. ;

Mattsson, Niklas ;

Mackin, R. Scott ;

Scholl, Michael ;

Nosheny, Rachel L. ;

Tosun, Duygu ;

Donohue, Michael C. ;

Aisen, Paul S. ;

Jagust, William J. ;

Weiner, Michael W. .

NEUROLOGY, 2016, 86 (20) :1887-1896

[6] A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer's disease [J].

Jessen, Frank ;

Amariglio, Rebecca E. ;

van Boxtel, Martin ;

Breteler, Monique ;

Ceccaldi, Mathieu ;

Chetelat, Gael ;

Dubois, Bruno ;

Dufouil, Carole ;

Ellis, Kathryn A. ;

van der Flier, Wiesje M. ;

Glodzik, Lidia ;

van Harten, Argonde C. ;

de Leon, Mony J. ;

McHugh, Pauline ;

Mielke, Michelle M. ;

Molinuevo, Jose Luis ;

Mosconi, Lisa ;

Osorio, Ricardo S. ;

Perrotin, Audrey ;

Petersen, Ronald C. ;

Rabin, Laura A. ;

Rami, Lorena ;

Reisberg, Barry ;

Rentz, Dorene M. ;

Sachdev, Perminder S. ;

de la Sayette, Vincent ;

Saykin, Andrew J. ;

Scheltens, Philip ;

Shulman, Melanie B. ;

Slavin, Melissa J. ;

Sperling, Reisa A. ;

Stewart, Robert ;

Uspenskaya, Olga ;

Vellas, Bruno ;

Visser, Pieter Jelle ;

Wagner, Michael .

ALZHEIMERS & DEMENTIA, 2014, 10 (06) :844-852

[7] CSF protein biomarkers predicting longitudinal reduction of CSF β-amyloid42 in cognitively healthy elders [J].

Mattsson, N. ;

Insel, P. ;

Nosheny, R. ;

Zetterberg, H. ;

Trojanowski, J. Q. ;

Shaw, L. M. ;

Tosun, D. ;

Weiner, M. .

TRANSLATIONAL PSYCHIATRY, 2013, 3 :e293-e293

[8] Predicting Reduction of Cerebrospinal Fluid β-Amyloid 42 in Cognitively Healthy Controls [J].

Mattsson, Niklas ;

Insel, Philip S. ;

Donohue, Michael ;

Jagust, William ;

Sperling, Reisa ;

Aisen, Paul ;

Weiner, Michael W. .

JAMA NEUROLOGY, 2015, 72 (05) :554-560

[9]

MCKHANN G, 1984, NEUROLOGY, V34, P939, DOI 10.1212/WNL.34.7.939

[10] The diagnosis of dementia due to Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease [J].

McKhann, Guy M. ;

Knopman, David S. ;

Chertkow, Howard ;

Hyman, Bradley T. ;

Jack, Clifford R., Jr. ;

Kawas, Claudia H. ;

Klunk, William E. ;

Koroshetz, Walter J. ;

Manly, Jennifer J. ;

Mayeux, Richard ;

Mohs, Richard C. ;

Morris, John C. ;

Rossor, Martin N. ;

Scheltens, Philip ;

Carrillo, Maria C. ;

Thies, Bill ;

Weintraub, Sandra ;

Phelps, Creighton H. .

ALZHEIMERS & DEMENTIA, 2011, 7 (03) :263-269

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