Effectiveness of varenicline and counselling for smoking cessation in an observational cohort study in China

被引:8
作者
Jiang, Bin [1 ]
He, Yao [2 ]
Zuo, Fang [1 ]
Wu, Lei [2 ]
Liu, Qing-Hui [3 ]
Zhang, Li [4 ]
Zhou, Chang -Xi [3 ]
Cheng, K. K. [5 ]
Chan, Sophia S. C. [6 ]
Lam, Tai Hing [7 ,8 ]
机构
[1] Chinese Peoples Liberat Army Gen Hosp, Dept Tradit Chinese Med & Acupuncture, Nanlou Fac Clin Med, Beijing, Peoples R China
[2] Chinese Peoples Liberat Army Gen Hosp, Beijing key Lab Aging & Geriatr, Inst Geriatr, Dept Epidemiol, Beijing, Peoples R China
[3] Chinese Peoples Liberat Army Gen Hosp, Dept Respirat, Nanlou Fac Clin Med, Beijing, Peoples R China
[4] Chinese Peoples Liberat Army Gen Hosp, Dept Rehabil, Nanlou Fac Clin Med, Beijing, Peoples R China
[5] Univ Birmingham, Publ Hlth Epidemiol & Biostat, Birmingham, W Midlands, England
[6] Univ Hong Kong, Sch Publ Hlth, Sch Nursing, Hong Kong, Hong Kong, Peoples R China
[7] Sch Publ Hlth, Dept Community Med, Hong Kong, Hong Kong, Peoples R China
[8] Univ Hong Kong, Hong Kong, Hong Kong, Peoples R China
基金
中国国家自然科学基金;
关键词
RECEPTOR PARTIAL AGONIST; SUSTAINED-RELEASE BUPROPION; PLACEBO; SMOKERS; AID; PREVALENCE; PREDICTORS; ABSTINENCE; EFFICACY; THERAPY;
D O I
10.1136/bmjopen-2015-009381
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objectives: To evaluate the effectiveness of varenicline for smoking cessation in Chinese smokers in a real world cessation clinic practice. Design: A prospective observational study. Setting: Beijing, China. Participants: A total of 924 smokers (883 men and 41 women) who attended a smoking cessation clinic of a large general hospital were assessed with data from structured questionnaires at baseline and follow-up at 1, 3 and 6 months. Trained physician counsellors provided free individual counselling for all subjects and follow-up interviews with brief counselling. 332 subjects additionally prescribed varenicline according to their own choice were compared with those without varenicline. Main Outcome Measures: Primary outcomes were self-reported 7-day point prevalence abstinence rate and 3-month continuous abstinence rate at 6-month follow-up. Secondary outcomes were 7-day point prevalence abstinence rates at 1 and 3-month follow-up, and 1-month continuous abstinence rate at 3-month follow-up. Results: By intention-to-treat, the 7-day point prevalence abstinence rate with varenicline and counselling at 6 months was significantly higher than counselling only (37.0% vs 23.1%; OR, 1.75; 95% CI 1.46 to 2.62; p=0.001). The 3-month continuous abstinence rate at 6 months was higher with varenicline (33.1% vs 18.4%; OR, 2.04; 95% CI 1.61 to 2.99; p<0.001). Varenicline also showed better secondary outcomes. Conclusions: Varenicline prescription in the smoking cessation clinic appeared to be effective with doubling of quit rates in Chinese smokers in a real world cessation clinic practice.
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页数:9
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