The p47phox PX domain: Two heads are better than one!

被引：15
|
作者：
Yaffe, MB [1 ]
机构：
[1] MIT, Ctr Canc Res, Cambridge, MA 02139 USA
来源：
STRUCTURE | 2002年 / 10卷 / 10期
关键词：
D O I：
10.1016/S0969-2126(02)00860-2
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The recent X-ray structure of the PX domain of p47phox, a critical subunit of the NADPH oxidase, unexpectedly revealed the presence of two distinct lipid binding pockets within this single modular domain. This unusual feature allows the p47phox PX domain to integrate signal transduction events emerging from two different lipid signaling pathways.
引用
收藏
页码：1288 / 1290
页数：3
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