Near-Infrared IIb Emitting Nanoprobe for High-Resolution Real-Time Imaging-Guided Photothermal Therapy Triggering Enhanced Anti-tumor Immunity

被引:28
作者
Huang, Biao [1 ]
Hu, Jun [2 ]
Li, Hao [3 ,4 ]
Luo, Meng-Yao [1 ]
Chen, Song [5 ]
Zhang, Mingxi [5 ]
Sun, Zhi-Jun [3 ,4 ]
Cui, Ran [1 ]
机构
[1] Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Peoples R China
[2] Huazhong Univ Sci & Technol, Coll Life Sci & Technol, Natl Engn Res Ctr Nanomed, Wuhan 430074, Peoples R China
[3] Wuhan Univ, Sch & Hosp Stomatol, State Key Lab Breeding Base Basic Sci Stomatol Hu, Wuhan 430079, Peoples R China
[4] Wuhan Univ, Sch & Hosp Stomatol, Key Lab Oral Biomed, Minist Educ, Wuhan 430079, Peoples R China
[5] Wuhan Univ Technol, State Key Lab Adv Technol Mat Synth & Proc, Wuhan 430070, Peoples R China
来源
ACS APPLIED BIO MATERIALS | 2020年 / 3卷 / 03期
基金
中国国家自然科学基金;
关键词
real-time imaging; photothermal therapy; NIR-II imaging; immune activation; microvessel density; THERANOSTIC AGENT; DENDRITIC CELLS; DRUG-DELIVERY; CANCER; NANOPARTICLES; COMBINATION; IMMUNOTHERAPY; NANOMEDICINE; ANGIOGENESIS; MECHANISMS;
D O I
10.1021/acsabm.9b01202
中图分类号
TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
The change of tumor vessels is an important indicator for the evolution of cancer, which largely reflects the curative degrees. Therefore, in situ monitoring of the change of tumor vessels during the course of medical treatment becomes an urgent need for the implementation of therapy. Photothermal therapy (PTT), a promising treatment for cancer, has attracted extensive attention. So far, it lacks precise methods for visualizing tumor vessels during the PTT treatment in a noninvasive way. Herein, the quantum-dot-based nanoprobes emitting in the 1500-1700 nm range of the second near-infrared region (NIR-IIb window) with good photothermal conversion performance are conjugated with arginine-glycine-aspartate peptide and successfully applied to imaging-guided photothermal therapy. Owing to the high resolution of NIR-IIb fluorescence imaging, the process of significant reduction of tumor-associated vessels and abnormal angiogenesis is clearly demonstrated. Encouragingly, the immune response can be activated after the photothermal therapy. Excellent therapeutic efficacy with suppressed recurrence is achieved under the synergistic effect of destroying tumor tissues and enhancing immunity. This work provides a noninvasive method to evaluate the changes of tumor microvessel density for anti-angiogenesis therapy and affords a powerful tool for in vivo research of preclinical animal models and precise cancer therapies.
引用
收藏
页码:1636 / 1645
页数:10
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