Gold Nanorod-Assisted Photothermal Therapy and Improvement Strategies

被引:53
作者
Taylor, Mitchell Lee [1 ]
Wilson, Raymond Edward, Jr. [1 ]
Amrhein, Kristopher Daniel [1 ]
Huang, Xiaohua [1 ]
机构
[1] Univ Memphis, Dept Chem, Memphis, TN 38152 USA
来源
BIOENGINEERING-BASEL | 2022年 / 9卷 / 05期
基金
美国国家卫生研究院;
关键词
gold nanorod; photothermal therapy; cancer; surface plasmon resonance;
D O I
10.3390/bioengineering9050200
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Noble metal nanoparticles have been sought after in cancer nanomedicine during the past two decades, owing to the unique localized surface plasmon resonance that induces strong absorption and scattering properties of the nanoparticles. A popular application of noble metal nanoparticles is photothermal therapy, which destroys cancer cells by heat generated by laser irradiation of the nanoparticles. Gold nanorods have stood out as one of the major types of noble metal nanoparticles for photothermal therapy due to the facile tuning of their optical properties in the tissue penetrative near infrared region, strong photothermal conversion efficiency, and long blood circulation half-life after surface modification with stealthy polymers. In this review, we will summarize the optical properties of gold nanorods and their applications in photothermal therapy. We will also discuss the recent strategies to improve gold nanorod-assisted photothermal therapy through combination with chemotherapy and photodynamic therapy.
引用
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页数:24
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