Pituitary adenylate cyclase activating peptide (PACAP) and the chemokine stromal cell-derived factor (SDF-1) have been implicated in neuroprotection, neurogenesis, and regeneration. Focal ischemia is associated with rapid upregulation of PACAP in perifocal neurons and delayed induction of SDF-1 in hypoxic/ischemic tissues, the latter process being involved in the recruitment of stem cells and inflammatory cells. Here, we studied mRNA patterns of PACAR SDF-1 and the cognate receptors PAC1 and CXCR4 by in situ hybridization in the rat hippocampus after transient global ischemia, a rat model for programmed death of CA1 pyramidal neurons. Cell death in CA1 was not associated with local induction of PACAP and SDF-1 expression or recruitment of CXCR4-expressing infiltrates. However, there was a transient, almost complete loss of SDF-1 expression in microvessels in all hippocampal regions. Granule cells transiently showed a decrease of SDF-1 and an increase of PACAP expression. While PAC1 mRNA was moderately decreased throughout the hippocampus, CXCR4 expression was selectively increased in the subgranular layer. We propose that altered PACAP and SDF-1 gene expression in granule cells plays a role in regulated neurogenesis after global ischemia. The finding that programmed neuronal death after global ischemia was not associated with SDF-1 upregulation or recruitment of CXCR4-expressing cells is in sharp contrast to SDF-1/CXCR4-mediated infiltration of infarct tissue after focal ischemia. Hence, the different modes of neuronal death after focal and global ischemia are associated with distinct SDF-1 and PACAP gene regulation patterns and distinct reorganization mechanisms. (C) 2009 Elsevier Ltd. All rights reserved.
机构:
Univ Calif Los Angeles, Mental Retardat Res Ctr, Semel Inst Neurosci, Dept Psychiat, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Mental Retardat Res Ctr, Semel Inst Neurosci, Dept Psychiat, Los Angeles, CA 90095 USA
Armstrong, B. D.
Abad, C.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Mental Retardat Res Ctr, Semel Inst Neurosci, Dept Psychiat, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Mental Retardat Res Ctr, Semel Inst Neurosci, Dept Psychiat, Los Angeles, CA 90095 USA
Abad, C.
Chhith, S.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Mental Retardat Res Ctr, Semel Inst Neurosci, Dept Psychiat, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Mental Retardat Res Ctr, Semel Inst Neurosci, Dept Psychiat, Los Angeles, CA 90095 USA
Chhith, S.
Cheling-Lau, G.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Mental Retardat Res Ctr, Semel Inst Neurosci, Dept Psychiat, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Mental Retardat Res Ctr, Semel Inst Neurosci, Dept Psychiat, Los Angeles, CA 90095 USA
Cheling-Lau, G.
Hajji, O. E.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Mental Retardat Res Ctr, Semel Inst Neurosci, Dept Psychiat, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Mental Retardat Res Ctr, Semel Inst Neurosci, Dept Psychiat, Los Angeles, CA 90095 USA
Hajji, O. E.
Noblita, H.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Mental Retardat Res Ctr, Semel Inst Neurosci, Dept Psychiat, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Mental Retardat Res Ctr, Semel Inst Neurosci, Dept Psychiat, Los Angeles, CA 90095 USA
Noblita, H.
Waschek, J. A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Mental Retardat Res Ctr, Semel Inst Neurosci, Dept Psychiat, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Mental Retardat Res Ctr, Semel Inst Neurosci, Dept Psychiat, Los Angeles, CA 90095 USA
机构:
Northwestern Univ, Dept Biol Chem & Mol Pharmacol, Feinberg Sch Med, Chicago, IL 60611 USANorthwestern Univ, Dept Biol Chem & Mol Pharmacol, Feinberg Sch Med, Chicago, IL 60611 USA
Bhattacharyya, Bula J.
Banisadr, Ghazal
论文数: 0引用数: 0
h-index: 0
机构:
Northwestern Univ, Dept Biol Chem & Mol Pharmacol, Feinberg Sch Med, Chicago, IL 60611 USANorthwestern Univ, Dept Biol Chem & Mol Pharmacol, Feinberg Sch Med, Chicago, IL 60611 USA
Banisadr, Ghazal
Jung, Hosung
论文数: 0引用数: 0
h-index: 0
机构:
Northwestern Univ, Dept Biol Chem & Mol Pharmacol, Feinberg Sch Med, Chicago, IL 60611 USANorthwestern Univ, Dept Biol Chem & Mol Pharmacol, Feinberg Sch Med, Chicago, IL 60611 USA
Jung, Hosung
Ren, Dongjun
论文数: 0引用数: 0
h-index: 0
机构:
Northwestern Univ, Dept Biol Chem & Mol Pharmacol, Feinberg Sch Med, Chicago, IL 60611 USANorthwestern Univ, Dept Biol Chem & Mol Pharmacol, Feinberg Sch Med, Chicago, IL 60611 USA
Ren, Dongjun
Cronshaw, Darran G.
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ, Coll Phys & Surg, Dept Microbiol, New York, NY 10032 USANorthwestern Univ, Dept Biol Chem & Mol Pharmacol, Feinberg Sch Med, Chicago, IL 60611 USA
Cronshaw, Darran G.
Zou, Yongrui
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ, Coll Phys & Surg, Dept Microbiol, New York, NY 10032 USANorthwestern Univ, Dept Biol Chem & Mol Pharmacol, Feinberg Sch Med, Chicago, IL 60611 USA
Zou, Yongrui
Miller, Richard J.
论文数: 0引用数: 0
h-index: 0
机构:
Northwestern Univ, Dept Biol Chem & Mol Pharmacol, Feinberg Sch Med, Chicago, IL 60611 USANorthwestern Univ, Dept Biol Chem & Mol Pharmacol, Feinberg Sch Med, Chicago, IL 60611 USA
机构:
NYU, Med Ctr, Sch Med, Lab Microvasc Res & Vasc Tissue Engn,Inst Reconst, New York, NY 10016 USANYU, Med Ctr, Sch Med, Lab Microvasc Res & Vasc Tissue Engn,Inst Reconst, New York, NY 10016 USA
Ceradini, DJ
Gurtner, GC
论文数: 0引用数: 0
h-index: 0
机构:
NYU, Med Ctr, Sch Med, Lab Microvasc Res & Vasc Tissue Engn,Inst Reconst, New York, NY 10016 USANYU, Med Ctr, Sch Med, Lab Microvasc Res & Vasc Tissue Engn,Inst Reconst, New York, NY 10016 USA
机构:
Henry Ford Hlth Systern, Dept Neurol, Detroit, MI USAHenry Ford Hlth Systern, Dept Neurol, Detroit, MI USA
Cui, Xu
Chen, Jieli
论文数: 0引用数: 0
h-index: 0
机构:
Henry Ford Hlth Systern, Dept Neurol, Detroit, MI USAHenry Ford Hlth Systern, Dept Neurol, Detroit, MI USA
Chen, Jieli
Zacharek, Alex
论文数: 0引用数: 0
h-index: 0
机构:
Henry Ford Hlth Systern, Dept Neurol, Detroit, MI USAHenry Ford Hlth Systern, Dept Neurol, Detroit, MI USA
Zacharek, Alex
Roberts, Cynthia
论文数: 0引用数: 0
h-index: 0
机构:
Henry Ford Hlth Systern, Dept Neurol, Detroit, MI USAHenry Ford Hlth Systern, Dept Neurol, Detroit, MI USA
Roberts, Cynthia
Yang, Yuping
论文数: 0引用数: 0
h-index: 0
机构:
Henry Ford Hlth Systern, Dept Neurol, Detroit, MI USAHenry Ford Hlth Systern, Dept Neurol, Detroit, MI USA
Yang, Yuping
Chopp, Michael
论文数: 0引用数: 0
h-index: 0
机构:
Henry Ford Hlth Systern, Dept Neurol, Detroit, MI USA
Oakland Univ, Dept Phys, Rochester, MI USAHenry Ford Hlth Systern, Dept Neurol, Detroit, MI USA
机构:Univ Rouen, INSERM U413, Lab Cellular & Mol Neuroendocrinol, European Inst Peptide Res IFRMP 23, F-76821 Mont St Aignan, France
Falluel-Morel, A.
Chafai, M.
论文数: 0引用数: 0
h-index: 0
机构:Univ Rouen, INSERM U413, Lab Cellular & Mol Neuroendocrinol, European Inst Peptide Res IFRMP 23, F-76821 Mont St Aignan, France
Chafai, M.
论文数: 引用数:
h-index:
机构:
Vaudry, D.
Basille, M.
论文数: 0引用数: 0
h-index: 0
机构:Univ Rouen, INSERM U413, Lab Cellular & Mol Neuroendocrinol, European Inst Peptide Res IFRMP 23, F-76821 Mont St Aignan, France
Basille, M.
Cazillis, M.
论文数: 0引用数: 0
h-index: 0
机构:Univ Rouen, INSERM U413, Lab Cellular & Mol Neuroendocrinol, European Inst Peptide Res IFRMP 23, F-76821 Mont St Aignan, France
Cazillis, M.
Aubert, N.
论文数: 0引用数: 0
h-index: 0
机构:Univ Rouen, INSERM U413, Lab Cellular & Mol Neuroendocrinol, European Inst Peptide Res IFRMP 23, F-76821 Mont St Aignan, France
Aubert, N.
Louiset, E.
论文数: 0引用数: 0
h-index: 0
机构:Univ Rouen, INSERM U413, Lab Cellular & Mol Neuroendocrinol, European Inst Peptide Res IFRMP 23, F-76821 Mont St Aignan, France
Louiset, E.
deJouffrey, S.
论文数: 0引用数: 0
h-index: 0
机构:Univ Rouen, INSERM U413, Lab Cellular & Mol Neuroendocrinol, European Inst Peptide Res IFRMP 23, F-76821 Mont St Aignan, France
deJouffrey, S.
Le Bigot, J. F.
论文数: 0引用数: 0
h-index: 0
机构:Univ Rouen, INSERM U413, Lab Cellular & Mol Neuroendocrinol, European Inst Peptide Res IFRMP 23, F-76821 Mont St Aignan, France
Le Bigot, J. F.
Fournier, A.
论文数: 0引用数: 0
h-index: 0
机构:Univ Rouen, INSERM U413, Lab Cellular & Mol Neuroendocrinol, European Inst Peptide Res IFRMP 23, F-76821 Mont St Aignan, France
Fournier, A.
Gressens, P.
论文数: 0引用数: 0
h-index: 0
机构:Univ Rouen, INSERM U413, Lab Cellular & Mol Neuroendocrinol, European Inst Peptide Res IFRMP 23, F-76821 Mont St Aignan, France
Gressens, P.
Rostene, W.
论文数: 0引用数: 0
h-index: 0
机构:Univ Rouen, INSERM U413, Lab Cellular & Mol Neuroendocrinol, European Inst Peptide Res IFRMP 23, F-76821 Mont St Aignan, France
Rostene, W.
Gressens, P.
论文数: 0引用数: 0
h-index: 0
机构:Univ Rouen, INSERM U413, Lab Cellular & Mol Neuroendocrinol, European Inst Peptide Res IFRMP 23, F-76821 Mont St Aignan, France
Gressens, P.
Rostene, W.
论文数: 0引用数: 0
h-index: 0
机构:Univ Rouen, INSERM U413, Lab Cellular & Mol Neuroendocrinol, European Inst Peptide Res IFRMP 23, F-76821 Mont St Aignan, France
Rostene, W.
Vaudry, H.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Rouen, INSERM U413, Lab Cellular & Mol Neuroendocrinol, European Inst Peptide Res IFRMP 23, F-76821 Mont St Aignan, FranceUniv Rouen, INSERM U413, Lab Cellular & Mol Neuroendocrinol, European Inst Peptide Res IFRMP 23, F-76821 Mont St Aignan, France
Vaudry, H.
Gonzalez, B. J.
论文数: 0引用数: 0
h-index: 0
机构:Univ Rouen, INSERM U413, Lab Cellular & Mol Neuroendocrinol, European Inst Peptide Res IFRMP 23, F-76821 Mont St Aignan, France
机构:
Univ Calif Los Angeles, Mental Retardat Res Ctr, Semel Inst Neurosci, Dept Psychiat, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Mental Retardat Res Ctr, Semel Inst Neurosci, Dept Psychiat, Los Angeles, CA 90095 USA
Armstrong, B. D.
Abad, C.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Mental Retardat Res Ctr, Semel Inst Neurosci, Dept Psychiat, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Mental Retardat Res Ctr, Semel Inst Neurosci, Dept Psychiat, Los Angeles, CA 90095 USA
Abad, C.
Chhith, S.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Mental Retardat Res Ctr, Semel Inst Neurosci, Dept Psychiat, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Mental Retardat Res Ctr, Semel Inst Neurosci, Dept Psychiat, Los Angeles, CA 90095 USA
Chhith, S.
Cheling-Lau, G.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Mental Retardat Res Ctr, Semel Inst Neurosci, Dept Psychiat, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Mental Retardat Res Ctr, Semel Inst Neurosci, Dept Psychiat, Los Angeles, CA 90095 USA
Cheling-Lau, G.
Hajji, O. E.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Mental Retardat Res Ctr, Semel Inst Neurosci, Dept Psychiat, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Mental Retardat Res Ctr, Semel Inst Neurosci, Dept Psychiat, Los Angeles, CA 90095 USA
Hajji, O. E.
Noblita, H.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Mental Retardat Res Ctr, Semel Inst Neurosci, Dept Psychiat, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Mental Retardat Res Ctr, Semel Inst Neurosci, Dept Psychiat, Los Angeles, CA 90095 USA
Noblita, H.
Waschek, J. A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Mental Retardat Res Ctr, Semel Inst Neurosci, Dept Psychiat, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Mental Retardat Res Ctr, Semel Inst Neurosci, Dept Psychiat, Los Angeles, CA 90095 USA
机构:
Northwestern Univ, Dept Biol Chem & Mol Pharmacol, Feinberg Sch Med, Chicago, IL 60611 USANorthwestern Univ, Dept Biol Chem & Mol Pharmacol, Feinberg Sch Med, Chicago, IL 60611 USA
Bhattacharyya, Bula J.
Banisadr, Ghazal
论文数: 0引用数: 0
h-index: 0
机构:
Northwestern Univ, Dept Biol Chem & Mol Pharmacol, Feinberg Sch Med, Chicago, IL 60611 USANorthwestern Univ, Dept Biol Chem & Mol Pharmacol, Feinberg Sch Med, Chicago, IL 60611 USA
Banisadr, Ghazal
Jung, Hosung
论文数: 0引用数: 0
h-index: 0
机构:
Northwestern Univ, Dept Biol Chem & Mol Pharmacol, Feinberg Sch Med, Chicago, IL 60611 USANorthwestern Univ, Dept Biol Chem & Mol Pharmacol, Feinberg Sch Med, Chicago, IL 60611 USA
Jung, Hosung
Ren, Dongjun
论文数: 0引用数: 0
h-index: 0
机构:
Northwestern Univ, Dept Biol Chem & Mol Pharmacol, Feinberg Sch Med, Chicago, IL 60611 USANorthwestern Univ, Dept Biol Chem & Mol Pharmacol, Feinberg Sch Med, Chicago, IL 60611 USA
Ren, Dongjun
Cronshaw, Darran G.
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ, Coll Phys & Surg, Dept Microbiol, New York, NY 10032 USANorthwestern Univ, Dept Biol Chem & Mol Pharmacol, Feinberg Sch Med, Chicago, IL 60611 USA
Cronshaw, Darran G.
Zou, Yongrui
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ, Coll Phys & Surg, Dept Microbiol, New York, NY 10032 USANorthwestern Univ, Dept Biol Chem & Mol Pharmacol, Feinberg Sch Med, Chicago, IL 60611 USA
Zou, Yongrui
Miller, Richard J.
论文数: 0引用数: 0
h-index: 0
机构:
Northwestern Univ, Dept Biol Chem & Mol Pharmacol, Feinberg Sch Med, Chicago, IL 60611 USANorthwestern Univ, Dept Biol Chem & Mol Pharmacol, Feinberg Sch Med, Chicago, IL 60611 USA
机构:
NYU, Med Ctr, Sch Med, Lab Microvasc Res & Vasc Tissue Engn,Inst Reconst, New York, NY 10016 USANYU, Med Ctr, Sch Med, Lab Microvasc Res & Vasc Tissue Engn,Inst Reconst, New York, NY 10016 USA
Ceradini, DJ
Gurtner, GC
论文数: 0引用数: 0
h-index: 0
机构:
NYU, Med Ctr, Sch Med, Lab Microvasc Res & Vasc Tissue Engn,Inst Reconst, New York, NY 10016 USANYU, Med Ctr, Sch Med, Lab Microvasc Res & Vasc Tissue Engn,Inst Reconst, New York, NY 10016 USA
机构:
Henry Ford Hlth Systern, Dept Neurol, Detroit, MI USAHenry Ford Hlth Systern, Dept Neurol, Detroit, MI USA
Cui, Xu
Chen, Jieli
论文数: 0引用数: 0
h-index: 0
机构:
Henry Ford Hlth Systern, Dept Neurol, Detroit, MI USAHenry Ford Hlth Systern, Dept Neurol, Detroit, MI USA
Chen, Jieli
Zacharek, Alex
论文数: 0引用数: 0
h-index: 0
机构:
Henry Ford Hlth Systern, Dept Neurol, Detroit, MI USAHenry Ford Hlth Systern, Dept Neurol, Detroit, MI USA
Zacharek, Alex
Roberts, Cynthia
论文数: 0引用数: 0
h-index: 0
机构:
Henry Ford Hlth Systern, Dept Neurol, Detroit, MI USAHenry Ford Hlth Systern, Dept Neurol, Detroit, MI USA
Roberts, Cynthia
Yang, Yuping
论文数: 0引用数: 0
h-index: 0
机构:
Henry Ford Hlth Systern, Dept Neurol, Detroit, MI USAHenry Ford Hlth Systern, Dept Neurol, Detroit, MI USA
Yang, Yuping
Chopp, Michael
论文数: 0引用数: 0
h-index: 0
机构:
Henry Ford Hlth Systern, Dept Neurol, Detroit, MI USA
Oakland Univ, Dept Phys, Rochester, MI USAHenry Ford Hlth Systern, Dept Neurol, Detroit, MI USA
机构:Univ Rouen, INSERM U413, Lab Cellular & Mol Neuroendocrinol, European Inst Peptide Res IFRMP 23, F-76821 Mont St Aignan, France
Falluel-Morel, A.
Chafai, M.
论文数: 0引用数: 0
h-index: 0
机构:Univ Rouen, INSERM U413, Lab Cellular & Mol Neuroendocrinol, European Inst Peptide Res IFRMP 23, F-76821 Mont St Aignan, France
Chafai, M.
论文数: 引用数:
h-index:
机构:
Vaudry, D.
Basille, M.
论文数: 0引用数: 0
h-index: 0
机构:Univ Rouen, INSERM U413, Lab Cellular & Mol Neuroendocrinol, European Inst Peptide Res IFRMP 23, F-76821 Mont St Aignan, France
Basille, M.
Cazillis, M.
论文数: 0引用数: 0
h-index: 0
机构:Univ Rouen, INSERM U413, Lab Cellular & Mol Neuroendocrinol, European Inst Peptide Res IFRMP 23, F-76821 Mont St Aignan, France
Cazillis, M.
Aubert, N.
论文数: 0引用数: 0
h-index: 0
机构:Univ Rouen, INSERM U413, Lab Cellular & Mol Neuroendocrinol, European Inst Peptide Res IFRMP 23, F-76821 Mont St Aignan, France
Aubert, N.
Louiset, E.
论文数: 0引用数: 0
h-index: 0
机构:Univ Rouen, INSERM U413, Lab Cellular & Mol Neuroendocrinol, European Inst Peptide Res IFRMP 23, F-76821 Mont St Aignan, France
Louiset, E.
deJouffrey, S.
论文数: 0引用数: 0
h-index: 0
机构:Univ Rouen, INSERM U413, Lab Cellular & Mol Neuroendocrinol, European Inst Peptide Res IFRMP 23, F-76821 Mont St Aignan, France
deJouffrey, S.
Le Bigot, J. F.
论文数: 0引用数: 0
h-index: 0
机构:Univ Rouen, INSERM U413, Lab Cellular & Mol Neuroendocrinol, European Inst Peptide Res IFRMP 23, F-76821 Mont St Aignan, France
Le Bigot, J. F.
Fournier, A.
论文数: 0引用数: 0
h-index: 0
机构:Univ Rouen, INSERM U413, Lab Cellular & Mol Neuroendocrinol, European Inst Peptide Res IFRMP 23, F-76821 Mont St Aignan, France
Fournier, A.
Gressens, P.
论文数: 0引用数: 0
h-index: 0
机构:Univ Rouen, INSERM U413, Lab Cellular & Mol Neuroendocrinol, European Inst Peptide Res IFRMP 23, F-76821 Mont St Aignan, France
Gressens, P.
Rostene, W.
论文数: 0引用数: 0
h-index: 0
机构:Univ Rouen, INSERM U413, Lab Cellular & Mol Neuroendocrinol, European Inst Peptide Res IFRMP 23, F-76821 Mont St Aignan, France
Rostene, W.
Gressens, P.
论文数: 0引用数: 0
h-index: 0
机构:Univ Rouen, INSERM U413, Lab Cellular & Mol Neuroendocrinol, European Inst Peptide Res IFRMP 23, F-76821 Mont St Aignan, France
Gressens, P.
Rostene, W.
论文数: 0引用数: 0
h-index: 0
机构:Univ Rouen, INSERM U413, Lab Cellular & Mol Neuroendocrinol, European Inst Peptide Res IFRMP 23, F-76821 Mont St Aignan, France
Rostene, W.
Vaudry, H.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Rouen, INSERM U413, Lab Cellular & Mol Neuroendocrinol, European Inst Peptide Res IFRMP 23, F-76821 Mont St Aignan, FranceUniv Rouen, INSERM U413, Lab Cellular & Mol Neuroendocrinol, European Inst Peptide Res IFRMP 23, F-76821 Mont St Aignan, France
Vaudry, H.
Gonzalez, B. J.
论文数: 0引用数: 0
h-index: 0
机构:Univ Rouen, INSERM U413, Lab Cellular & Mol Neuroendocrinol, European Inst Peptide Res IFRMP 23, F-76821 Mont St Aignan, France