Mercaptoacyl matrix metalloproteinase inhibitors: The effect of substitution at the mercaptoacyl moiety

被引：19

作者：

Baxter, AD

Bhogal, R

Bird, JB

Buckley, GM

Gregory, DS

Hedger, PC

Manallack, DT

Massil, T

Minton, KJ

Montana, JG

Neidle, S

Owen, DA

Watson, RJ

机构：

[1] CHIROSCI LTD,CAMBRIDGE CB4 4WE,ENGLAND

[2] INST CANC RES,CRC,BIOMOL STRUCT UNIT,SUTTON SM2 5NG,SURREY,ENGLAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 21期

关键词：

D O I：

10.1016/S0960-894X(97)10069-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The in vitro potency of orally-active mercaptoacyl matrix metalloproteinase inhibitors is increased by the introduction of appropriate substituents on the mercaptoacyl moiety. (C) 1997 Elsevier Science Ltd.

引用

页码：2765 / 2770

页数：6

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