Intracellular RNA and nuclear DNA-dual-targeted tumor therapy via upconversion nanoplatforms with UCL/MR dual-mode bioimaging

被引：16

作者：

Teng, Bo ^{[1
]}

Ding, Binbin ^{[2
,3
]}

Shao, Shuai ^{[2
]}

Wang, Zhanfeng ^{[4
]}

Tong, Weifang ^{[1
]}

Wang, Sanchun ^{[1
]}

Cheng, Ziyong ^{[2
,3
]}

Lin, Jun ^{[2
,3
]}

Ma, Ping'an ^{[1
,2
,3
]}

机构：

[1] Second Hosp Jilin Univ, Dept Otolaryngol Head & Neck Surg, Changchun 130041, Peoples R China

[2] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Rare Earth Resource Utilizat, Changchun 130022, Peoples R China

[3] Univ Sci & Technol China, Hefei 230026, Peoples R China

[4] Third Hosp Jilin Univ, Dept Neurosurg, Changchun 130033, Peoples R China

来源：

CHEMICAL ENGINEERING JOURNAL | 2021年 / 405卷

基金：

中国国家自然科学基金;

关键词：

Protein therapy; Upconversion nanoparticles; RNase A; Dual-mode bioimaging; Large-pore mesoporous silica;

D O I：

10.1016/j.cej.2020.126606

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Despite remarkable progresses in nucleic acid-targeted tumor therapy, intracellular RNA and nuclear DNA-dual targeted cancer treatments via a single nano-delivery system have been little investigated. Herein, cis-platinum pro-drugs (DSP) and cytotoxic protein ribonuclease A (RNase A) dual-therapeutic agents-loaded large-pore mesoporous silica-coated beta-NaYF4:20%Yb,2%Er@beta-NaGdF4 upconversion nanoplatforms (UCSPtR) were prepared for chemo-protein combination therapy. The obtained upconversion nanoplatforms can not only transport cytotoxic protein molecules and DSP into tumor cells to induce intracellular RNA degradation-mediated and nuclear DNA-targeted killings of cancer cells, but also achieve upconversion luminescence (UCL) and magnetic resonance (MR) dual-mode bioimaging. We believe this RNA and DNA-dual-targeted nanosystem will provide more enlightenments for tumor therapy.

引用

页数：8

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