In vitro Antimicrobial Activity of Acne Drugs Against Skin-Associated Bacteria

被引:53
作者
Blaskovich, Mark A. T. [1 ]
Elliott, Alysha G. [1 ]
Kavanagh, Angela M. [1 ]
Ramu, Soumya [1 ]
Cooper, Matthew A. [1 ]
机构
[1] Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia
基金
英国惠康基金;
关键词
BENZOYL PEROXIDE; AZELAIC ACID; PROPIONIBACTERIUM-ACNES; ANTIBACTERIAL ACTIVITY; STAPHYLOCOCCUS-AUREUS; SALICYLATE;
D O I
10.1038/s41598-019-50746-4
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Acne is a common skin affliction that involves excess sebum production and modified lipid composition, duct blockage, colonization by bacteria, and inflammation. Acne drugs target one or more of these steps, with antibiotics commonly used to treat the microbial infection for moderate to severe cases. Whilst a number of other acne therapies are purported to possess antimicrobial activity, this has been poorly documented in many cases. We conducted a comparative analysis of the activity of common topical acne drugs against the principal etiological agent associated with acne: the aerotolerant anaerobic Gram-positive organism Propionibacterium acnes (recently renamed as Cutibacterium acnes). We also assessed their impact on other bacteria that could also be affected by topical treatments, including both antibiotic-sensitive and antibiotic-resistant strains, using broth microdilution assay conditions. Drugs designated specifically as antibiotics had the greatest potency, but lost activity against resistant strains. The non-antibiotic acne agents did possess widespread antimicrobial activity, including against resistant strains, but at substantially higher concentrations. Hence, the antimicrobial activity of non-antibiotic acne agents may provide protection against a background of increased drug-resistant bacteria.
引用
收藏
页数:8
相关论文
共 47 条
[1]  
Adler BL, 2017, JAMA DERMATOL, V153, P810, DOI [10.1001/jamadermatol.2017.1297, 10.1001/jamadermatol.2017.2103]
[2]   Why we continue to use the name Propionibacterium acnes [J].
Alexeyev, O. A. ;
Dekio, I. ;
Layton, A. M. ;
Li, H. ;
Hughes, H. ;
Morris, T. ;
Zouboulis, C. C. ;
Patrick, S. .
BRITISH JOURNAL OF DERMATOLOGY, 2018, 179 (05) :1227-1227
[3]  
American Academy of Dermatology Practice Management Center, TOP THER REC
[4]   TOPICAL AZELAIC ACID AND THE TREATMENT OF ACNE - A CLINICAL AND LABORATORY COMPARISON WITH ORAL TETRACYCLINE [J].
BLADON, PT ;
BURKE, BM ;
CUNLIFFE, WJ ;
FORSTER, RA ;
HOLLAND, KT ;
KING, K .
BRITISH JOURNAL OF DERMATOLOGY, 1986, 114 (04) :493-499
[5]   THE INVITRO ANTIMICROBIAL EFFECTS OF AZELAIC ACID UPON PROPIONIBACTERIUM-ACNES STRAIN-P37 [J].
BOJAR, RA ;
HOLLAND, KT ;
CUNLIFFE, WJ .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1991, 28 (06) :843-853
[6]   Human skin commensals augment Staphylococcus aureus pathogenesis [J].
Boldock, Emma ;
Surewaard, Bas G. J. ;
Shamarina, Darla ;
Na, Manli ;
Fei, Ying ;
Ali, Abukar ;
Williams, Alexander ;
Pollitt, Eric J. G. ;
Szkuta, Piotr ;
Morris, Paul ;
Prajsnar, Tomasz K. ;
McCoy, Kathy D. ;
Jin, Tao ;
Dockrell, David H. ;
van Strijp, Jos A. G. ;
Kubes, Paul ;
Renshaw, Stephen A. ;
Foster, Simon J. .
NATURE MICROBIOLOGY, 2018, 3 (08) :881-890
[7]   Microbial biofilms and the human skin microbiome [J].
Brandwein, Michael ;
Steinberg, Doron ;
Meshner, Shiri .
NPJ BIOFILMS AND MICROBIOMES, 2016, 2
[8]   The human skin microbiome [J].
Byrd, Allyson L. ;
Belkaid, Yasmine ;
Segre, Julia A. .
NATURE REVIEWS MICROBIOLOGY, 2018, 16 (03) :143-155
[9]   THE EFFECT OF BENZOYL PEROXIDE ON CUTANEOUS MICROORGANISMS INVITRO [J].
COVE, JH ;
HOLLAND, KT .
JOURNAL OF APPLIED BACTERIOLOGY, 1983, 54 (03) :379-382
[10]   EVOLUTION OF A STRATEGY FOR THE TREATMENT OF ACNE [J].
CUNLIFFE, WJ .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 1987, 16 (03) :591-599