Phenotypic and Genotypic Characterization of Enterobacteriaceae with Decreased Susceptibility to Carbapenems: Results from Large Hospital-Based Surveillance Studies in China

被引：68
作者：
Yang, Qiwen [1 ]
Wang, Hui [1 ]
Sun, Hongli [1 ]
Chen, Hongbin [1 ]
Xu, Yingchun [1 ]
Chen, Minjun [1 ]
机构：
[1] Chinese Acad Med Sci, Dept Clin Lab, Peking Union Med Coll Hosp, Peking Union Med Coll, Beijing 100730, Peoples R China
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2010年 / 54卷 / 01期
关键词：
HYDROLYZING BETA-LACTAMASE; KLEBSIELLA-PNEUMONIAE; ESCHERICHIA-COLI; IMIPENEM RESISTANCE; SERRATIA-MARCESCENS; MULTIPLEX PCR; UNITED-STATES; GENES; KPC-2; PREVALENCE;
D O I：
10.1128/AAC.01099-09
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The resistance mechanism of 49 Enterobacteriaceae isolates with decreased susceptibility to carbapenems collected from 2004 to 2008 at 16 teaching hospitals in China was investigated. Moderate- to high-level carbapenem resistance in most isolates was more closely associated with loss or decreased expression of both major porins combined with production of AmpC or extended-spectrum beta-lactamase enzymes, while KPC-2, IMP-4, and IMP-8 carbapenemase production may lead to a low to moderate level of carbapenem resistance in Enterobacteriaceae in China.
引用
收藏
页码：573 / 577
页数：5
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