Intraarterial delivery of virotherapy for glioblastoma

被引：18

作者：

Srinivasan, Visish M. ^{[1
]}

Lang, Frederick F. ^{[2
]}

Kan, Peter ^{[3
]}

机构：

[1] Barrow Neurol Inst, Dept Neurosurg, Phoenix, AZ 85013 USA

[2] Univ Texas MD Anderson Canc Ctr, Dept Neurosurg, Houston, TX 77030 USA

[3] Univ Texas Med Branch, Dept Neurosurg, Galveston, TX 77555 USA

来源：

NEUROSURGICAL FOCUS | 2021年 / 50卷 / 02期

关键词：

endovascular; intraarterial; glioblastoma; virotherapy; oncolytic; stem cell; HEPATIC ARTERIAL INFUSION; MESENCHYMAL STEM-CELLS; ONCOLYTIC ADENOVIRUS; RECURRENT GLIOBLASTOMA; HERPES-VIRUS; PHASE-I; THERAPY; CANCER; GLIOMA; MUTANT;

D O I：

10.3171/2020.11.FOCUS20845

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Oncolytic viruses (OVs) have been used in the treatment of cancer, in a focused manner, since the 1990s. These OVs have become popular in the treatment of several cancers but are only now gaining interest in the treatment of glioblastome (GBM) in recent clinical trials. In this review, the authors discuss the unique applications of intraarterial (IA) delivery of OVs, starting with concepts of OV, how they apply to IA delivery, and concluding with discussion of the current ongoing trials. Several OVs have been used in the treatment of GBM, including specifically several modified adenoviruses. IA delivery of OVs has been performed in the hepatic circulation and is now being studied in the cerebral circulation to help enhance delivery and specificity. There are some interesting synergies with immunotherapy and IA delivery of OVs. Some of the shortcomings are discussed, specifically the systemic response to OVs and feasibility of treatment. Future studies can be performed in the preclinical setting to identify the ideal candidates for translation into clinical trials, as well as the nuances of this novel delivery method.

引用

页码：1 / 9

页数：9

共 60 条

[1] Viruses in cancer treatment [J].

Alemany, R. .

CLINICAL & TRANSLATIONAL ONCOLOGY, 2013, 15 (03) :182-188

[2] The combined effects of oncolytic reovirus plus Newcastle disease virus and reovirus plus parvovirus on U87 and U373 cells in vitro and in vivo [J].

Alkassar, Muhannad ;

Gaertner, Barbara ;

Roemer, Klaus ;

Graesser, Friedrich ;

Rommelaere, Jean ;

Kaestner, Lars ;

Haeckel, Isabelle ;

Graf, Norbert .

JOURNAL OF NEURO-ONCOLOGY, 2011, 104 (03) :715-727

[3] ICOVIR-5 shows E2F1 addiction and potent antiglioma effect in vivo [J].

Alonso, Marta M. ;

Cascallo, Manel ;

Gomez-Manzano, Candelaria ;

Jiang, Hong ;

Bekele, B. Nebiyou ;

Perez-Gimenez, Anna ;

Lang, Frederick F. ;

Piao, Yuji ;

Alemany, Ramon ;

Fueyo, Juan .

CANCER RESEARCH, 2007, 67 (17) :8255-8263

[4] An adenovirus mutant that replicates selectively in p53-deficient human tumor cells [J].

Bischoff, JR ;

Kim, DH ;

Williams, A ;

Heise, C ;

Horn, S ;

Muna, M ;

Ng, L ;

Nye, JA ;

SampsonJohannes, A ;

Fattaey, A ;

McCormick, F .

SCIENCE, 1996, 274 (5286) :373-376

[5] Safety and maximum tolerated dose of superselective intraarterial cerebral infusion of bevacizumab after osmotic blood-brain barrier disruption for recurrent malignant glioma Clinical article [J].

Boockvar, John A. ;

Tsiouris, Apostolos J. ;

Hofstetter, Christoph P. ;

Kovanlikaya, Ilhami ;

Fralin, Sherese ;

Kesavabhotla, Kartik ;

Seedial, Stephen M. ;

Pannullo, Susan C. ;

Schwartz, Theodore H. ;

Stieg, Philip ;

Zimmerman, Robert D. ;

Knopman, Jared ;

Scheff, Ronald J. ;

Christos, Paul ;

Vallabhajosula, Shankar ;

Riina, Howard A. .

JOURNAL OF NEUROSURGERY, 2011, 114 (03) :624-632

[6] The Somatic Genomic Landscape of Glioblastoma [J].

Brennan, Cameron W. ;

Verhaak, Roel G. W. ;

McKenna, Aaron ;

Campos, Benito ;

Noushmehr, Houtan ;

Salama, Sofie R. ;

Zheng, Siyuan ;

Chakravarty, Debyani ;

Sanborn, J. Zachary ;

Berman, Samuel H. ;

Beroukhim, Rameen ;

Bernard, Brady ;

Wu, Chang-Jiun ;

Genovese, Giannicola ;

Shmulevich, Ilya ;

Barnholtz-Sloan, Jill ;

Zou, Lihua ;

Vegesna, Rahulsimham ;

Shukla, Sachet A. ;

Ciriello, Giovanni ;

Yung, W. K. ;

Zhang, Wei ;

Sougnez, Carrie ;

Mikkelsen, Tom ;

Aldape, Kenneth ;

Bigner, Darell D. ;

Van Meir, Erwin G. ;

Prados, Michael ;

Sloan, Andrew ;

Black, Keith L. ;

Eschbacher, Jennifer ;

Finocchiaro, Gaetano ;

Friedman, William ;

Andrews, David W. ;

Guha, Abhijit ;

Iacocca, Mary ;

O'Neill, Brian P. ;

Foltz, Greg ;

Myers, Jerome ;

Weisenberger, Daniel J. ;

Penny, Robert ;

Kucherlapati, Raju ;

Perou, Charles M. ;

Hayes, D. Neil ;

Gibbs, Richard ;

Marra, Marco ;

Mills, Gordon B. ;

Lander, Eric ;

Spellman, Paul ;

Wilson, Richard .

CELL, 2013, 155 (02) :462-477

[7] Malignant Glioma: Lessons from Genomics, Mouse Models, and Stem Cells [J].

Chen, Jian ;

Mckay, Renee M. ;

Parada, Luis F. .

CELL, 2012, 149 (01) :36-47

[8] Preclinical Toxicology of rQNestin34.5v.2: An Oncolytic Herpes Virus with Transcriptional Regulation of the ICP34.5 Neurovirulence Gene [J].

Chiocca, E. Antonio ;

Nakashima, Hiroshi ;

Kasai, Kazue ;

Fernandez, Soledad A. ;

Oglesbee, Michael .

MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT, 2020, 17 :871-893

[9] The role of STAT3 in tumor-mediated immune suppression [J].

Ferguson, Sherise D. ;

Srinivasan, Visish M. ;

Heimberger, Amy B. .

JOURNAL OF NEURO-ONCOLOGY, 2015, 123 (03) :385-394

[10] Recurrent glioma clinical trial, CheckMate-143: the game is not over yet [J].

Filley, Anna C. ;

Henriquez, Mario ;

Dey, Mahua .

ONCOTARGET, 2017, 8 (53) :91779-91794

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