Evolution of DNA and RNA as catalysts for chemical reactions

被引：40

作者：

Jäschke, A ^{[1
]}

Seelig, B ^{[1
]}

机构：

[1] Free Univ Berlin, Dept biol Chem & Pharm, Inst Chem, D-14195 Berlin, Germany

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2000年 / 4卷 / 03期

关键词：

D O I：

10.1016/S1367-5931(00)00086-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In vitro selection from combinatorial nucleic acid libraries has provided new RNA and DNA molecules that have catalytic properties. Catalyzed reactions now go far beyond self-modifying reactions of nucleic acid molecules. The future application of in vitro selected RNA and DNA catalysts in bioorganic synthesis appears promising.

引用

页码：257 / 262

页数：6

共 23 条

[1]

Bartel DP, 1999, TRENDS CELL BIOL, V9, pM9, DOI 10.1016/S0968-0004(99)01483-8

[2] Nucleic acid enzymes [J].

Carola, C ;

Eckstein, F .

CURRENT OPINION IN CHEMICAL BIOLOGY, 1999, 3 (03) :274-283

[3] Cholesterol esterase activity by in vitro selection of RNA against a phosphate transition-state analogue [J].

Chun, SM ;

Jeong, SJ ;

Kim, JM ;

Chong, BO ;

Park, YK ;

Park, H ;

Yu, J .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1999, 121 (46) :10844-10845

[4] The joys of in vitro selection: chemically dressing oligonucleotides to satiate protein targets [J].

Eaton, BE .

CURRENT OPINION IN CHEMICAL BIOLOGY, 1997, 1 (01) :10-16

[5] Oligonucleotide libraries - variatio delectat [J].

Famulok, M ;

Jenne, A .

CURRENT OPINION IN CHEMICAL BIOLOGY, 1998, 2 (03) :320-327

[6] A tiny RNA that catalyzes both aminoacyl-RNA and peptidyl-RNA synthesis [J].

Illangasekare, M ;

Yarus, M .

RNA, 1999, 5 (11) :1482-1489

[7] Specific, rapid synthesis of Phe-RNA by RNA [J].

Illangasekare, M ;

Yarus, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (10) :5470-5475

[8]

Jäschke A, 1999, SYNLETT, P825

[9]

Koizumi M, 1999, NAT STRUCT BIOL, V6, P1062

[10] Emergence of a dual-catalytic RNA with metal-specific cleavage and ligase activities: The spandrels of RNA evolution [J].

Landweber, LF ;

Pokrovskaya, ID .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (01) :173-178

← 1 2 3 →