Does epigenetics play a role in human asthma?

被引：24

作者：

Vercelli, Donata ^{[1
,2
]}

机构：

[1] Univ Arizona, Arizona Resp Ctr, Dept Cellular & Mol Med, Rm 339,1657 E Helen St, Tucson, AZ 85721 USA

[2] Univ Arizona, Arizona Ctr Biol Complex Dis ABCD, Inst BIO5, Rm 339,1657 E Helen St, Tucson, AZ 85721 USA

来源：

ALLERGOLOGY INTERNATIONAL | 2016年 / 65卷 / 02期

关键词：

Allergy; Birth cohort; Childhood asthma; DNA methylation; Epigenetics; TOTAL IGE LEVELS; DNA METHYLATION; CHILDHOOD ASTHMA; CHILDREN; RISK; INTERLEUKIN-13; PREDICTORS; METHYLOME; EXPOSURE; DISEASE;

D O I：

10.1016/j.alit.2015.12.001

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Asthma and other allergic diseases are among the most prevalent chronic non-communicable diseases of childhood. According to the World Health Organization, asthma affects >7.0 million children under 18 in the United States, with an economic burden that is estimated to exceed that of tuberculosis and HIV/AIDS combined. Despite much research, the natural history of asthma and its pathogenesis are still in many ways elusive. This review discusses our current understanding of the role epigenetic processes play in asthma pathogenesis, focusing on genome-wide, population-based studies. Copyright (C) 2015, Japanese Society of Allergology. Production and hosting by Elsevier B.V.

引用

页码：123 / 126

页数：4

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