Fluorescent Probes and Labels for Cellular Imaging

被引：5
|
作者：
Fahrni, Christoph J. [1 ,2 ]
机构：
[1] Georgia Inst Technol, Sch Chem & Biochem, Atlanta, GA 30332 USA
[2] Georgia Inst Technol, Petit Inst Bioengn & Biosci, Atlanta, GA 30332 USA
来源：
CHIMIA | 2009年 / 63卷 / 11期
基金：
美国国家卫生研究院;
关键词：
Excited state proton transfer; Imaging; Photoinduced electron transfer; Trace metals; X-ray fluorescence microscopy; INTRAMOLECULAR PROTON-TRANSFER; ELECTRON-TRANSFER; 2-(2'-ARYLSULFONAMIDOPHENYL)BENZIMIDAZOLE DERIVATIVES; SENSORS; EMISSION; TOPOGRAPHY; MICROSCOPY; LIGATION; DESIGN; COPPER;
D O I：
10.2533/chimia.2009.714
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Metal-responsive fluorescent indicators are powerful tools for visualizing trace metals with subcellular resolution. By taking advantage of the diverse photophysical properties of organic fluorophores, metal ion-selective fluorescent indicators have been rationally designed and tailored towards cellular applications. This review summarizes challenges associated with the probe design and describes recent efforts in our research group in developing selective and sensitive reagents for the detection of zinc and copper in mammalian cells.
引用
收藏
页码：714 / 720
页数：7
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