Comparison of Clinical Features and Outcomes in Epithelial Ovarian Cancer according to Tumorigenicity in Patient-Derived Xenograft Models

被引:19
作者
Eoh, Kyung Jin [1 ]
Chung, Young Shin [1 ]
Lee, So Hyun [1 ]
Park, Sun-Ae [1 ]
Kim, Hee Jung [1 ]
Yang, Wookyeom [2 ]
Lee, In Ok [1 ]
Lee, Jung-Yun [1 ]
Cho, Hanbyoul [2 ]
Chay, Doo Byung [2 ]
Kim, Sunghoon [1 ]
Kim, Sang Wun [1 ]
Kim, Jae-Hoon [2 ]
Kim, Young Tae [1 ]
Nam, Eun Ji [1 ]
机构
[1] Yonsei Univ, Coll Med, Inst Womens Life Med Sci, Dept Obstet & Gynecol, 50-1 Yonsei Ro, Seoul 03722, South Korea
[2] Yonsei Univ, Coll Med, Gangnam Severance Hosp, Dept Obstet & Gynecol, Seoul, South Korea
来源
CANCER RESEARCH AND TREATMENT | 2018年 / 50卷 / 03期
基金
新加坡国家研究基金会;
关键词
Ovarian neoplasms; Progression-free survival; Patient-derived xenograft; TUMOR XENOGRAFTS; GROWTH; WOMEN;
D O I
10.4143/crt.2017.181
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Purpose Although the use of xenograft models is increasing, few studies have compared the clinical features or outcomes of epithelial ovarian cancer (EOC) patients according to the tumorigenicity of engrafted specimens. The purpose of this study was to evaluate whether tumorigenicity was associated with the clinical features and outcomes of EOC patients. Materials and Methods Eighty-eight EOC patients who underwent primary or interval debulking surgery from June 2014 to December 2015 were included. Fresh tumor specimens were implanted subcutaneously on each flank of immunodeficient mice. Patient characteristics, progression-free survival (PFS), and germline mutation spectra were compared according to tumorigenicity. Results Xenografts were established successfully from 49 of 88 specimens. Tumorigenicity was associated with lymphovascular invasion and there was a propensity to engraft successfully with high-grade tumors. Tumors from patients who underwent non-optimal (residual disease. 1 cm) primary or interval debulking surgery had a significantly greater propensity to achieve tumorigenicity than those who received optimal surgery. In addition, patients whose tumors became engrafted seemed to have a shorter PFS and more frequent germline mutations than patients whose tumors failed to engraft. Tumorigenicity was a significant factor for predicting PFS with advanced International Federation of Gynecology and Obstetrics stage and high-grade cancers. Conclusion Tumorigenicity in a xenograft model was a strong prognostic factor and was associated with more aggressive tumors in EOC patients. Xenograft models can be useful as a preclinical tool to predict prognosis and could be applied to further pharmacologic and genomic studies on personalized treatments.
引用
收藏
页码:956 / 963
页数:8
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