Synthesis and antibacterial activity of 1β-methyl-2-(5-substituted thiazolo pyrrolidin-3-ylthio)carbapenem derivatives

被引：55

作者：

Oh, CH

Cho, HW

Baek, D

Cho, JH ^{[1
]}

机构：

[1] Korea Inst Sci & Technol, Med Chem Res Ctr, Seoul 130650, South Korea

[2] Hanseo Univ, Dept Chem, Seosan 356706, South Korea

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2002年 / 37卷 / 09期

关键词：

1; beta-methylcarbapenem; antibacterial activity; substituent effect;

D O I：

10.1016/S0223-5234(02)01397-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of a new series of 1beta-methylcarbapenems having the substituted thiazolopyrrolidine moiety is described. Their in vitro antibacterial activities against both Gram-positive including, MRSA and Gram-negative bacteria were tested and the effect of substituent on the thiazole ring was investigated. A particular compound (28c) having 4-amide substituted thiazole moiety showed the most potent antibacterial activity. (C) 2002 Published by Editions scientifiques et medicales Elsevier SAS.

引用

页码：743 / 754

页数：12

共 12 条

[1]

Coulton S, 1996, Prog Med Chem, V33, P99, DOI 10.1016/S0079-6468(08)70304-7

[2] Structure-activity relationships of cephalosporin derivatives against methicillin-resistant Staphylococcus aureus and Enterococcus faecalis [J].