Comparison of molecularly imprinted, mixed-mode and hydrophilic balance sorbents performance in the solid-phase extraction of amphetamine drugs from wastewater samples for liquid chromatography-tandem mass spectrometry determination

被引:63
作者
Gonzalez-Marino, Iria [1 ]
Benito Quintana, Jose [1 ]
Rodriguez, Isaac [1 ]
Rodil, Rosario [1 ]
Gonzalez-Penas, Javier [1 ]
Cela, Rafael [1 ]
机构
[1] Univ Santiago de Compostela, IIAA Inst Food Anal & Res, Dept Analyt Chem Nutr & Food Sci, Santiago De Compostela 15782, Spain
关键词
Molecularly imprinted polymers; Solid-phase extraction; Illicit drugs; Liquid chromatography-mass spectrometry; Matrix effects; Wastewater; PERSONAL CARE PRODUCTS; ILLICIT DRUGS; SURFACE-WATER; STIMULATORY DRUGS; ENDOCRINE DISRUPTORS; AIRBORNE PARTICLES; COCAINE; METABOLITES; ABUSE; PHARMACEUTICALS;
D O I
10.1016/j.chroma.2009.09.069
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Recent studies have shown that amphetamines and other drugs of abuse residues occur in wastewater. Consequently, several methods have been developed for their determination by solid-phase extraction (SPE) and liquid chromatography-tandem mass spectrometry (LC-MS/MS). However, a major drawback of these methods is the lack of selectivity during SPE that results in reduced sensitivity, due to matrix effects, and in some cases in low precision and poor accuracy. In order to tackle this problem, three different SPE alternatives have been evaluated in this work for the determination of five amphetamines: common hydrophilic balance (Oasis HLB), mixed-mode (Oasis MCX) and molecularly imprinted polymers (MIPs) sorbents. Among them, Oasis HLB showed the worst performance, as three amphetamines (MDA, MDMA and MDEA) could not be determined because of interfering signals in the LC-MS/MS chromatogram, and amphetamine recoveries could not be corrected by the use of the deuterated analogue internal standard. Oasis MCX permitted the determination of all target analytes, but with still strong signal suppression: ca. 70% signal drop with wastewater samples, which could in this case be corrected by the internal standards providing acceptable trueness (overall recoveries: 101-137%), precision (RSD: 2.0-12%) and limits of detection (LOD: 1.5-4.4 ng/L). Alternatively, MIPs rendered cleaner extracts with less matrix effects (ca. 30% signal drop), and thus lower LODs (0.5-2.7 ng/L) and even better trueness (91-114% overall recovery) and precision (1.5-4.4%RSD). The final application of the method with MIP cartridges showed the presence of MDA and MDMA in the seven analysed wastewaters at the 4-20 ng/L level. (C) 2009 Elsevier B.V. All rights reserved.
引用
收藏
页码:8435 / 8441
页数:7
相关论文
共 38 条
[1]  
[Anonymous], 2002, Off. J. Eur. Comm, VL221, P8
[2]   Evaluation of principal cannabinoids in airborne particulates [J].
Balducci, C. ;
Nervegna, G. ;
Cecinato, A. .
ANALYTICA CHIMICA ACTA, 2009, 641 (1-2) :89-94
[3]   Simultaneous ultra-high-pressure liquid chromatography-tandem mass spectrometry determination of amphetamine and amphetamine-like stimulants, cocaine and its metabolites, and a cannabis metabolite in surface water and urban wastewater [J].
Bijlsma, Lubertus ;
Sancho, Juan V. ;
Pitarch, Elena ;
Ibanez, Maria ;
Hernandez, Felix .
JOURNAL OF CHROMATOGRAPHY A, 2009, 1216 (15) :3078-3089
[4]   Trace determination of cannabinoids and opiates in wastewater and surface waters by ultra-performance liquid chromatography-tandem mass spectrometry [J].
Boleda, M. Rosa ;
Galceran, M. Teresa ;
Ventura, Francesc .
JOURNAL OF CHROMATOGRAPHY A, 2007, 1175 (01) :38-48
[5]   Using environmental analytical data to estimate levels of community consumption of illicit drugs and abused pharmaceuticals [J].
Bones, Jonathan ;
Thomas, Kevin V. ;
Paull, Brett .
JOURNAL OF ENVIRONMENTAL MONITORING, 2007, 9 (07) :701-707
[6]   Mass spectrometric analysis of illicit drugs in wastewater and surface water [J].
Castiglioni, Sara ;
Zuccato, Ettore ;
Chiabrando, Chiara ;
Fanelli, Roberto ;
Bagnati, Renzo .
MASS SPECTROMETRY REVIEWS, 2008, 27 (04) :378-394
[7]   Identification and measurement of illicit drugs and their metabolites in urban wastewater by liquid chromatography-tandem mass spectrometry [J].
Castiglioni, Sara ;
Zuccato, Ettore ;
Crisci, Elisabetta ;
Chiabrando, Chiara ;
Fanelli, Roberto ;
Bagnati, Renzo .
ANALYTICAL CHEMISTRY, 2006, 78 (24) :8421-8429
[8]   Occurrence of cocaine in the air of the World's cities An emerging problem? A new tool to investigate the social incidence of drugs? [J].
Cecinato, Angelo ;
Balducci, Catia ;
Nervegna, Graziano .
SCIENCE OF THE TOTAL ENVIRONMENT, 2009, 407 (05) :1683-1690
[9]   Detection of cocaine in the airborne particles of the Italian cities Rome and Taranto [J].
Cecinato, Angelo ;
Balducci, Catia .
JOURNAL OF SEPARATION SCIENCE, 2007, 30 (12) :1930-1935
[10]   Eliminating Solid Phase Extraction with Large-Volume Injection LC/MS/MS: Analysis of Illicit and Legal Drugs and Human Urine Indicators in US Wastewaters [J].
Chiaia, Aurea C. ;
Banta-Green, Cale ;
Field, Jennifer .
ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2008, 42 (23) :8841-8848