Investigation of the influence on conformational transition of DNA induced by cationic lipid vesicles

被引：7
|
作者：
Zhang, ZL [1 ]
Huang, WM [1 ]
Wang, EK [1 ]
Dong, SJ [1 ]
机构：
[1] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Electroanalyt Chem, Changchun 130022, Peoples R China
来源：
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY | 2003年 / 59卷 / 02期
关键词：
voltammetry; spectroscopy; DDAB; DNA; conformational transition;
D O I：
10.1016/S1386-1425(02)00177-4
中图分类号：
O433 [光谱学];
学科分类号：
0703 ; 070302 ;
摘要：
Recent studies have focused on the structural features of DNA-lipid assemblies. In this paper we take nile blue A (NBA) as a probe molecule to study the influence of the conformational transition of DNA induced by didodecyldimethylammonium bromide (DDAB) cationic vesicles to the interaction between DNA and the probe molecules. We find that upon binding to DNA, a secondary conformational transition of DNA induced by the cationic liposome from the native B-form to the C-form resulted in the change of binding modes of NBA to DNA and different complexes are formed between DNA, DDAB and NBA. (C) 2002 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：255 / 263
页数：9
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