Antibacterial Activity of Lipophilic Fluoroquinolone Derivatives

被引：6

作者：

de Almeida, Camila G. ^{[1
]}

Diniz, Claudio G. ^{[2
]}

Silva, Vania L. ^{[2
]}

Saraiva, Mauricio F. ^{[1
]}

Le Hyaric, Mireille ^{[1
]}

de Almeida, Mauro V. ^{[1
]}

机构：

[1] Univ Fed Juiz De Fora, Inst Ciencias Exatas, Dept Quim, BR-36036900 Juiz De Fora, MG, Brazil

[2] Univ Fed Juiz De Fora, Dept Parasitol Microbiol & Imunol, BR-36036900 Juiz De Fora, MG, Brazil

来源：

MEDICINAL CHEMISTRY | 2009年 / 5卷 / 05期

关键词：

Fluoroquinolones; lipophilicity; antibacterial activity; gatifloxacin; moxifloxacin; diamines; alkyl chains; BAY; 12-8039; TUBERCULOSIS; MOXIFLOXACIN; AGENTS;

D O I：

10.2174/157340609789117859

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We report in this work the antibacterial evaluation of 12 lipophilic fluoroquinolone derivatives containing diaminoalkyl side chains at C-7 position. The compounds were investigated against 15 bacterial strains including Gram-negative and Gram-positive species of clinical and microbiological importance. Three compounds (5, 10 and 11) were as active as or more efficient than gatifloxacin against Gram-positive bacteria M. lentus. When compared with gatifloxacin compound 10 was 16 times more active. Two compounds (11 and 12) were twice more active than the reference compound against S. aureus.

引用

页码：419 / 421

页数：3

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