Gout: optimizing treatment to achieve a disease cure

被引：29
作者：
Antonio Bernal, Jose [1 ]
Quilis, Neus [1 ]
Andres, Mariano [1 ]
Sivera, Francisca [2 ]
Pascual, Eliseo [1 ,3 ]
机构：
[1] Hosp Gen Univ Alicante, Secc Reumatol, Pintor Baeza 12, Alicante 03010, Spain
[2] Hosp Gen Univ Elda, Secc Reumatol, Alicante, Spain
[3] Univ Miguel Hernandez, Dept Med Reumatol, Alicante, Spain
来源：
THERAPEUTIC ADVANCES IN CHRONIC DISEASE | 2016年 / 7卷 / 02期
关键词：
allopurinol; colchicine; gout; monosodium urate crystals; uric acid; EVIDENCE-BASED RECOMMENDATIONS; RANDOMIZED CONTROLLED-TRIAL; URIC-ACID METABOLISM; DOUBLE-BLIND; SYNOVIAL-FLUID; CLINICAL-TRIAL; TRIAMCINOLONE ACETONIDE; CONVENTIONAL TREATMENT; ALLOPURINOL THERAPY; INTERCRITICAL GOUT;
D O I：
10.1177/2040622315618393
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Gout is one of the most common inflammatory arthritides. The disease is due to the deposition of monosodium urate crystals. These deposits are reversible with proper treatment, suggesting that gout is a curable disease. The main aim in gout is to lower serum uric acid levels to a pre-established target; there are different urate-lowering drugs (xanthine oxidase inhibitors, uricosurics and uricases) through which this can be achieved. Proper treatment of gout also involves correct management of acute flares and their prevention. To ensure treatment adherence it is necessary to explain to the patient what the objectives are.
引用
收藏
页码：135 / 144
页数：10
相关论文
共 84 条
  • [1] Febuxostat Hypersensitivity
    Abeles, Aryeh M.
    [J]. JOURNAL OF RHEUMATOLOGY, 2012, 39 (03) : 659 - 660
  • [2] DOES COLCHICINE WORK - THE RESULTS OF THE 1ST CONTROLLED-STUDY IN ACUTE GOUT
    AHERN, MJ
    REID, C
    GORDON, TP
    MCCREDIE, M
    BROOKS, PM
    JONES, M
    [J]. AUSTRALIAN AND NEW ZEALAND JOURNAL OF MEDICINE, 1987, 17 (03): : 301 - 304
  • [3] ALLOWAY JA, 1993, J RHEUMATOL, V20, P111
  • [4] Bardin T., 2015, ANN RHEUM DIS S, V74, P574
  • [5] HYPERTRIGLYCERIDEMIA AND HYPERURICEMIA - EFFECTS OF 2 FIBRIC ACID-DERIVATIVES (BEZAFIBRATE AND FENOFIBRATE) IN A DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL
    BASTOW, MD
    DURRINGTON, PN
    ISHOLA, M
    [J]. METABOLISM-CLINICAL AND EXPERIMENTAL, 1988, 37 (03): : 217 - 220
  • [6] Febuxostat compared with allopurinol in patients with hyperuricemia and gout
    Becker, MA
    Schumacher, HR
    Wortmann, RL
    MacDonald, PA
    Eustace, D
    Palo, WA
    Streit, J
    Joseph-Ridge, N
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2005, 353 (23) : 2450 - 2461
  • [7] Long-term safety of pegloticase in chronic gout refractory to conventional treatment
    Becker, Michael A.
    Baraf, Herbert S. B.
    Yood, Robert A.
    Dillon, Aileen
    Vazquez-Mellado, Janitzia
    Ottery, Faith D.
    Khanna, Dinesh
    Sundy, John S.
    [J]. ANNALS OF THE RHEUMATIC DISEASES, 2013, 72 (09) : 1469 - 1474
  • [8] Beutler AM, 2001, CLIN EXP RHEUMATOL, V19, P595
  • [9] Borstad GC, 2004, J RHEUMATOL, V31, P2429
  • [10] Campion E W, 1987, Am J Med, V82, P421, DOI 10.1016/0002-9343(87)90441-4
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