Cobalt(II) Diphenylazodioxide Complexes Induce Apoptosis in SK-HEP-1 Cells

被引：22

作者：

Alghamdi, Norah J. ^{[1
,2
,3
]}

Balaraman, Lakshmi ^{[1
]}

Emhoff, Kylin A. ^{[1
]}

Salem, Ahmed M. H. ^{[1
]}

Wei, Ruhan ^{[1
,2
]}

Zhou, Aimin ^{[1
,2
]}

Boyd, W. Christopher ^{[1
]}

机构：

[1] Cleveland State Univ, Dept Chem, 2121 Euclid Ave, Cleveland, OH 44114 USA

[2] Cleveland State Univ, Ctr Gene Regulat Hlth & Dis GRHD, 2121 Euclid Ave, Cleveland, OH 44114 USA

[3] Univ Louisville Hosp, Dept Pathol & Lab Med, Clin Chem Fellowship Program, Louisville, KY 40206 USA

来源：

ACS OMEGA | 2019年 / 4卷 / 11期

关键词：

SURFACTANT-COBALT(III) COMPLEXES; STRUCTURAL-CHARACTERIZATION; RHODIUM(III) COMPLEX; NICKEL(II) COMPLEXES; CYTOTOXIC ACTIVITY; CMC DETERMINATION; METAL-COMPLEXES; DNA-BINDING; INHIBITOR; PHOTOCHEMISTRY;

D O I：

10.1021/acsomega.9b01684

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The cobalt(II) complex salts [Co(bpy)(az)(2)](PF6)(2) and [Co(az)(4)](PF6), each bearing the unusual cis-N,N'-diphenylazodioxide ligand, were both screened as possible anticancer agents against SK-HEP-1 liver cancer cells. Both compounds were found to induce substantial apoptosis as an increasing function of concentration and time. Measurement of apoptosis-related proteins indicated that both the extrinsic and intrinsic pathways of apoptosis were activated. The apoptotic activity induced by these salts is not displayed either by simple cobalt(II) salts or complexes or by the free nitrosobenzene ligand. Additionally, these compounds did not induce apoptosis, as assessed by poly(adenosine diphosphate-ribose) polymerase cleavage, in several other cell lines.

引用

页码：14503 / 14510

页数：8

共 60 条

[31] A novel scandium ortho-methoxynitrosobenzene-dimer complex: mechanistic implications for the nitroso-Diels-Alder reaction
Lightfoot, AP
Pritchard, RG
Wan, H
Warren, JE
Whiting, A
[J]. CHEMICAL COMMUNICATIONS, 2002, (18) : 2072 - 2073
[32] Metallodrugs in Medicinal Inorganic Chemistry
Mjos, Katja Dralle
Orvig, Chris
[J]. CHEMICAL REVIEWS, 2014, 114 (08) : 4540 - 4563
[33] COBALT(II)-CATALYZED CONVERSION OF ALLYLIC ALCOHOLS ACETATES TO ALLYLIC AMIDES IN THE PRESENCE OF NITRILES
MUKHOPADHYAY, M
REDDY, MM
MAIKAP, GC
IQBAL, J
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1995, 60 (09) : 2670 - 2676
[34] Synthesis, Micellization Behaviour, DNA/RNA Binding and Biological Studies of a Surfactant Cobalt(III) Complex With Dipyrido[3,2-a:2',4'-c](6,7,8,9-tetrahydro)phenazine
Nagaraj, Karuppiah
Murugan, Krishnan Senthil
Thangamuniyandi, Pilavadi
Sakthinathan, Subramanian
[J]. JOURNAL OF FLUORESCENCE, 2014, 24 (06) : 1701 - 1714
[35] Synthesis, CMC determination, nucleic acid binding and cytotoxicity of a surfactant-cobalt(III) complex: effect of ionic liquid additive
Nagaraj, Karuppiah
Arunachalam, Sankaralingam
[J]. NEW JOURNAL OF CHEMISTRY, 2014, 38 (01) : 366 - 375
[36] Nami SAA, 2006, J CHEM RES-S, P563
[37] Solvent assisted synthesis, structural characterization and biological evaluation of cobalt(II) and nickel(II) complexes of Schiff bases generated from benzyl carbazate and cyclic ketones
Nithya, Palanivelu
Rajamanikandan, Ramar
Simpson, Jim
Ilanchelian, Malaichamy
Govindarajan, Subbiah
[J]. POLYHEDRON, 2018, 145 : 200 - 217
[38] High in vivo antitumor activity of cobalt oxoisoaporphine complexes by targeting G-quadruplex DNA, telomerase and disrupting mitochondrial functions
Qin, Qi-Pin
Qin, Jiao-Lan
Meng, Ting
Lin, Wan-Hua
Zhang, Chuan-Hui
Wei, Zu-Zhuang
Chen, Jia-Nian
Liu, Yan-Cheng
Liang, Hong
Chen, Zhen-Feng
[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2016, 124 : 380 - 392
[39] Ravi Ch., 2016, Int. J. Pharm. Sci. Rev. Res, V41, P372
[40] PLATINUM COMPOUNDS - A NEW CLASS OF POTENT ANTITUMOUR AGENTS
ROSENBERG, B
VANCAMP, L
TROSKO, JE
MANSOUR, VH
[J]. NATURE, 1969, 222 (5191) : 385 - +

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