Cobalt(II) Diphenylazodioxide Complexes Induce Apoptosis in SK-HEP-1 Cells

被引：22

作者：

Alghamdi, Norah J. ^{[1
,2
,3
]}

Balaraman, Lakshmi ^{[1
]}

Emhoff, Kylin A. ^{[1
]}

Salem, Ahmed M. H. ^{[1
]}

Wei, Ruhan ^{[1
,2
]}

Zhou, Aimin ^{[1
,2
]}

Boyd, W. Christopher ^{[1
]}

机构：

[1] Cleveland State Univ, Dept Chem, 2121 Euclid Ave, Cleveland, OH 44114 USA

[2] Cleveland State Univ, Ctr Gene Regulat Hlth & Dis GRHD, 2121 Euclid Ave, Cleveland, OH 44114 USA

[3] Univ Louisville Hosp, Dept Pathol & Lab Med, Clin Chem Fellowship Program, Louisville, KY 40206 USA

来源：

ACS OMEGA | 2019年 / 4卷 / 11期

关键词：

SURFACTANT-COBALT(III) COMPLEXES; STRUCTURAL-CHARACTERIZATION; RHODIUM(III) COMPLEX; NICKEL(II) COMPLEXES; CYTOTOXIC ACTIVITY; CMC DETERMINATION; METAL-COMPLEXES; DNA-BINDING; INHIBITOR; PHOTOCHEMISTRY;

D O I：

10.1021/acsomega.9b01684

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The cobalt(II) complex salts [Co(bpy)(az)(2)](PF6)(2) and [Co(az)(4)](PF6), each bearing the unusual cis-N,N'-diphenylazodioxide ligand, were both screened as possible anticancer agents against SK-HEP-1 liver cancer cells. Both compounds were found to induce substantial apoptosis as an increasing function of concentration and time. Measurement of apoptosis-related proteins indicated that both the extrinsic and intrinsic pathways of apoptosis were activated. The apoptotic activity induced by these salts is not displayed either by simple cobalt(II) salts or complexes or by the free nitrosobenzene ligand. Additionally, these compounds did not induce apoptosis, as assessed by poly(adenosine diphosphate-ribose) polymerase cleavage, in several other cell lines.

引用

页码：14503 / 14510

页数：8

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