Colorectal cancer in the course of familial adenomatous polyposis: natural history and treatment methods

被引：0

作者：

Gronowska, Agata M. ^{[1
]}

Gluszek, Stanislaw ^{[1
,2
,3
]}

Bicki, Jacek ^{[1
,4
]}

Matykiewicz, Jaroslaw ^{[3
,4
]}

机构：

[1] Jan Kochanowski Univ, Inst Med Sci, Dept Surg Med, Lab Med Genet, Kielce, Poland

[2] Reg Hosp, Dept Clin Gen Oncol & Endocrinol Surg, Kielce, Poland

[3] Holy Cross Canc Ctr, Dept Surg Oncol, Kielce, Poland

[4] Jan Kochanowski Univ, Coll Med, Kielce, Poland

来源：

MEDICAL STUDIES-STUDIA MEDYCZNE | 2020年 / 36卷 / 04期

关键词：

colorectal cancer; familial adenomatous polyposis; familial polyposis coli; APC gene mutation; POUCH-ANAL ANASTOMOSIS; SURGICAL-TREATMENT; ILEAL POUCH; ILEORECTAL ANASTOMOSIS; APC GENE; MANAGEMENT; MUTATION; COLECTOMY; SULINDAC;

D O I：

10.5114/ms.2020.102325

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Familial adenomatous polyposis (FAP) is a group of diseases, mostly caused by an APC suppressor gene mutation inherited in an autosomal dominant pattern. It results in numerous adenomas formed in the epithelium of the large intestine leading to colorectal cancer in 100% of cases, with the mean age of 39, and a high risk of other fatal neoplasms. There is no causative treatment possible. Total colectomy performed at the right time is the only way to prevent the individual from developing colorectal cancer. The aim of this study was to present the diagnostic performance and treatment methods of FAP. Fast diagnosis and strict surveillance of patients and their families are the most important for effective treatment.

引用

页码：302 / 308

页数：7

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