Protection against Japanese encephalitis virus strains representing four genotypes by passive transfer of sera raised against ChimeriVax™-JE experimental vaccine

被引：64
作者：
Beasley, DWC
Li, L
Suderman, MT
Guirakhoo, F
Trent, DW
Monath, TP
Shope, RE
Barrett, ADT
机构：
[1] Univ Texas, Med Branch, Sealy Ctr Vaccine Dev, Dept Pathol, Galveston, TX 77555 USA
[2] Univ Texas, Med Branch, Ctr Biofedense & Emerging Infect Dis, Galveston, TX 77555 USA
[3] Acambis Inc, Res & Med Affairs, Cambridge, MA 02139 USA
来源：
VACCINE | 2004年 / 22卷 / 27-28期
关键词：
Japanese encephalitis virus; ChimeriVax (TM)-JE; genotype;
D O I：
10.1016/j.vaccine.2004.03.027
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The ability of antiscra raised against a candidate Japanese encephalitis virus (JEV) vaccine, ChimeriVax(TM)-JE, and the currently licensed vaccine, JE-VAX(R), to protect against strains of JEV representing the four major genotypes was assessed. Neutralization assays and passive protection studies in mice showed that greatest protection was provided against strains of genotypes II and III, although some protection was also afforded against genotypes I and IV strains. Chimerivax(TM)-JE stimulated protection that was comparable or superior to the JE-VAX(R) control. (C) 2004 Elsevier Ltd. All rights reserved.
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收藏
页码：3722 / 3726
页数：5
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