Visible-Light-Initiated One-Pot, Three-Component Synthesis of 2-Amino-4H-pyran-3,5-dicarbonitrile Derivatives

被引：51

作者：

Zhang, Mo ^{[1
]}

Chen, Meng-Nan ^{[1
]}

Li, Jiao-Mian ^{[1
]}

Liu, Nan ^{[1
]}

Zhang, Zhan-Hui ^{[1
]}

机构：

[1] Hebei Normal Univ, Coll Chem & Mat Sci, Natl Demonstrat Ctr Expt Chem Educ, Hebei Key Lab Organ Funct Mol, 20 South Second Ring East Rd, Shijiazhuang 050024, Hebei, Peoples R China

来源：

ACS COMBINATORIAL SCIENCE | 2019年 / 21卷 / 10期

基金：

中国国家自然科学基金;

关键词：

visible light; catalyst-free; 2-amino-4H-pyran-3,5-dicarbonitrile; spirooxindoles; multicomponent reaction; green synthesis; MULTICOMPONENT SYNTHESIS; CATALYST-FREE; PYRAN DERIVATIVES; EFFICIENT; SOLVENT; THIOPHENE; PYRIDINE; GREEN;

D O I：

10.1021/acscombsci.9b00124

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A novel approach for the visible -light-initiated synthesis of 2-amino-4H-pyran-3,5-dicarbonitrile derivatives via a one -pot, three -component reaction of aldehydes or isatins, malononitrile, and alpha-cyano ketones has been developed. The reaction was carried out at room temperature in ethanol/water to give the corresponding products with a wide range of functional groups in high yields. This process did not require any additives or chromatographic separation and could be applied for gram-scale synthesis.

引用

页码：685 / 691

页数：7

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