Simple method for determination of terbutaline plasma concentration by high-performance liquid chromatography

被引：25
作者：
Herring, VL
Johnson, JA
机构：
[1] Univ Florida, Dept Pharm Practice, Gainesville, FL 32610 USA
[2] Univ Tennessee, Coll Pharm, Dept Clin Pharm, Memphis, TN 38163 USA
来源：
JOURNAL OF CHROMATOGRAPHY B | 2000年 / 741卷 / 02期
关键词：
terbutaline;
D O I：
10.1016/S0378-4347(00)00107-9
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A method is described in which low nanomolar concentrations of terbutaline in plasma can be quantitated by use of a standard isocratic high-performance liquid chromatography system with electrochemical detection. Samples were prepared for injection by solid-phase extraction and preserved from degradation by addition of glutathione. Terbutaline and internal standard metaproterenol were resolved from plasma constituents on a single C-18 column by ion-pairing chromatography. The method is precise and accurate for measurement of freebase concentrations as low as 4.4 nmol/l (1 ng/ml). (C) 2000 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：307 / 312
页数：6
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