Update on histopathological evaluation of lymphadenectomy specimens from prostate cancer patients

被引：17
作者：
Conti, Alessandro [1 ]
Santoni, Matteo [2 ]
Burattini, Luciano [2 ]
Scarpelli, Marina [3 ]
Mazzucchelli, Roberta [3 ]
Galosi, Andrea B. [1 ]
Cheng, Liang [4 ]
Lopez-Beltran, Antonio [5 ]
Briganti, Alberto [6 ]
Montorsi, Francesco [6 ]
Montironi, Rodolfo [3 ]
机构：
[1] Marche Polytech Univ, Dept Odontostomatol & Specialized Clin Sci, Urol Sect, Sch Med, Via Conca 71, I-60126 Ancona, Italy
[2] Univ Politecn Marche, Azienda Osped Univ Osped Riuniti Umberto I, Med Oncol, Via Conca 71, I-60126 Ancona, Italy
[3] Marche Polytech Univ, AOU Osped Riuniti, Sect Pathol Anat, Sch Med, Via Conca 71, I-60126 Ancona, Italy
[4] Indiana Univ Sch Med, Dept Pathol & Lab Med, Indianapolis, IN 46202 USA
[5] Univ Cordoba, Dept Surg, Sch Med, Cordoba, Spain
[6] IRCCS Osped San Raffaele, Unit Urol, Div Oncol, URI, Milan, Italy
来源：
WORLD JOURNAL OF UROLOGY | 2017年 / 35卷 / 04期
关键词：
Prostate cancer; Lymph nodes; Metastases; LYMPH-NODE METASTASES; GLEASON SCORE 3+3=6; NEOADJUVANT HORMONAL-THERAPY; POLYMERASE-CHAIN-REACTION; RECURRENCE-FREE SURVIVAL; RADICAL PROSTATECTOMY; PELVIC LYMPHADENECTOMY; BIOCHEMICAL RECURRENCE; EXTRANODAL EXTENSION; REAL-TIME;
D O I：
10.1007/s00345-015-1752-8
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
The metastatic detection rate can vary according to the approach adopted in the microscopic analysis of the LNs, which includes frozen-section examination, total inclusion of the tissue with and without whole-mount sections, serial sectioning, and the application of immunohistochemistry. The assessment of the sentinel LN, the search for micrometastases, and the evaluation of atypical LN metastatic sites further contribute to the detection of the metastatic spread. In this review, an update on the histopathological evaluation of LND specimens in patients with PCa is given, and focus is made on their clinical and prognostic significance.
引用
收藏
页码：517 / 526
页数：10
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