Complex evaluation in patients with knee osteoarthritis

被引:1
作者
Traistaru, Magdalena Rodica [1 ]
Kamal, Diana [2 ]
Maria, Daniela Teodora [3 ]
Zorila, Marian Valentin [4 ]
Alexandru, Dragos Ovidiu [5 ]
Rogoveanu, Otilia Constantina [1 ]
Radu, Mirela [6 ]
Kamal, Kamal Constantin [6 ]
机构
[1] Univ Med & Pharm Craiova, Dept Phys & Rehabil Med, Craiova, Romania
[2] Elga Clin, Dept Phys & Rehabil Med, 2 Mihai Eminescu St, Craiova 200131, Romania
[3] Univ Med & Pharm Craiova, Dept Nephrol, Craiova, Romania
[4] Univ Med & Pharm Craiova, Dept Forens Med, Craiova, Romania
[5] Univ Med & Pharm Craiova, Dept Med Informat & Biostat, 2 Petru Rares St, Craiova 200349, Romania
[6] Univ Med & Pharm Craiova, Dept Family Med, Craiova, Romania
关键词
osteoarthritis; knee; serum CTX-II; histology; II COLLAGEN; CTX-II; CARTILAGE HISTOPATHOLOGY; BIOCHEMICAL MARKERS; SERUM BIOMARKERS; DEGRADATION; PROGRESSION; EPIDEMIOLOGY; FRAGMENTS; EXERCISE;
D O I
暂无
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Knee osteoarthritis (KOA) is a very common, slowly progressive and incurable articular disease resulting in the breakdown of cartilage and bone in the joint, which causes significant discomfort, pain and disability, with a significant socio-economic impact. The aim of our observational study for patients with symptomatic KOA was to investigate the changes of C-terminal telopeptide of type II collagen (CTX-II) in serum pre and post a complex rehabilitation program and to establish the correlation between all studied parameters [clinical, functional, serum CTX-II (sCTX-II) and histological aspects obtained through arthroscopy]. During 2016-2017, we performed an observational study including 24 patients, between 59 and 76 years old, diagnosed with KOA. Studied patients were completely assessed before (T1) and four months after a complex rehabilitation program (T2). The measured parameters were stiffness, pain, and physical function and we used the Visual Analogue Scale (VAS) for pain, with Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), sCTX-II value obtained by enzyme-linked immunosorbent assay (ELISA) test, histological assessment of knee cartilage after arthroscopy. In the histological assessment of our patients, we observed that the cells of the superficial areas were round and hypertrophic, the cartilage tissue had few proteoaminoglycans and glycosaminoglycans, with an airy aspect of the matrix and degenerate cells, numerically reduced. After positive diagnosis, the complete treatment, including the rehabilitation program, seems to be the ideal option for improving the CTX-II values, as well as the quality of life in KOA patients.
引用
收藏
页码:167 / 174
页数:8
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