Breakthrough in Stem Cell Research? The Reprogramming of Somatic Cells to Pluripotent Stem Cells: Overview and Outlook

被引：0

作者：

Greber, Boris ^{[1
]}

Schoeler, Hans ^{[1
]}

机构：

[1] Max Planck Inst Mol Biomed, Dept Cell & Dev Biol, Rontgenstr 20, D-48149 Munster, Germany

来源：

IS THIS CELL A HUMAN BEING? EXPLORING THE STATUS OF EMBRYOS, STEM CELLS AND HUMAN-ANIMAL HYBRIDS | 2011年

关键词：

Cell explantation; Cell fusion; Cell nuclear transfer; Defined factors; Reprogramming; MOUSE EMBRYONIC FIBROBLASTS; DEVELOPMENTAL REGULATORS; GENERATION; INDUCTION; CHROMATIN; OCT4; DIFFERENTIATION; BLASTOCYSTS; EXPRESSION; CIRCUITRY;

D O I：

10.1007/978-3-642-20772-3_2

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Human embryonic stem (ES) cells are capable of generating all cell types and tissues of the body. As such they represent an attractive source for therapeutic approaches. However, transplanted cells may be rejected by the immune system. One way to address this problem is to generate patient-specific ES cells. This, however, requires the transformation of the genetic program of somatic cells back to that of an early embryonic state. The field of stem cell research and reprogramming is rapidly evolving. This chapter aims at providing background information to understand some of the most exciting recent developments. Subsequently, the different existing strategies of converting somatic cells into ES-like cells will be reviewed and evaluated.

引用

页码：7 / 24

页数：18

共 73 条

[1] The mammalian epigenome [J].

Bernstein, Bradley E. ;

Meissner, Alexander ;

Lander, Eric S. .

CELL, 2007, 128 (04) :669-681

[2] Oct4 distribution and level in mouse clones:: consequences for pluripotency [J].

Boiani, M ;

Eckardt, S ;

Schöler, HR ;

McLaughlin, KJ .

GENES & DEVELOPMENT, 2002, 16 (10) :1209-1219

[3] Polycomb complexes repress developmental regulators in murine embryonic stem cells [J].

Boyer, LA ;

Plath, K ;

Zeitlinger, J ;

Brambrink, T ;

Medeiros, LA ;

Lee, TI ;

Levine, SS ;

Wernig, M ;

Tajonar, A ;

Ray, MK ;

Bell, GW ;

Otte, AP ;

Vidal, M ;

Gifford, DK ;

Young, RA ;

Jaenisch, R .

NATURE, 2006, 441 (7091) :349-353

[4] Core transcriptional regulatory circuitry in human embryonic stem cells [J].

Boyer, LA ;

Lee, TI ;

Cole, MF ;

Johnstone, SE ;

Levine, SS ;

Zucker, JR ;

Guenther, MG ;

Kumar, RM ;

Murray, HL ;

Jenner, RG ;

Gifford, DK ;

Melton, DA ;

Jaenisch, R ;

Young, RA .

CELL, 2005, 122 (06) :947-956

[5] ES cells derived from cloned and fertilized blastocysts are transcriptionally and functionally indistinguishable [J].

Brambrink, T ;

Hochedlinger, K ;

Bell, G ;

Jaenisch, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (04) :933-938

[6] Sequential expression of pluripotency markers during direct reprogramming of mouse somatic cells [J].

Brambrink, Tobias ;

Foreman, Ruth ;

Welstead, G. Grant ;

Lengner, Christopher J. ;

Wernig, Marius ;

Suh, Heikyung ;

Jaenisch, Rudolf .

CELL STEM CELL, 2008, 2 (02) :151-159

[7] Producing primate embryonic stem cells by somatic cell nuclear transfer [J].

Byrne, J. A. ;

Pedersen, D. A. ;

Clepper, L. L. ;

Nelson, M. ;

Sanger, W. G. ;

Gokhale, S. ;

Wolf, D. P. ;

Mitalipov, S. M. .

NATURE, 2007, 450 (7169) :497-U3

[8] Birth of Parthenote Mice Directly from Parthenogenetic Embryonic Stem Cells [J].

Chen, Zhisheng ;

Liu, Zhong ;

Huang, Junjiu ;

Amano, Tomokazu ;

Li, Chao ;

Cao, Shanbo ;

Wu, Chao ;

Liu, Bodu ;

Zhou, Lingjun ;

Carter, Mark G. ;

Keefe, David L. ;

Yang, Xiangzhong ;

Liu, Lin .

STEM CELLS, 2009, 27 (09) :2136-2145

[9] RETRACTED: Generation of pluripotent stem cells from adult human testis (Retracted article. See vol. 512, pg. 338, 2014) [J].

Conrad, Sabine ;

Renninger, Markus ;

Hennenlotter, Joerg ;

Wiesner, Tina ;

Just, Lothar ;

Bonin, Michael ;

Aicher, Wilhelm ;

Buehring, Hans-Joerg ;

Mattheus, Ulrich ;

Mack, Andreas ;

Wagner, Hans-Joachim ;

Minger, Stephen ;

Matzkies, Matthias ;

Reppel, Michael ;

Hescheler, Juergen ;

Sievert, Karl-Dietrich ;

Stenzl, Arnulf ;

Skutella, Thomas .

NATURE, 2008, 456 (7220) :344-U25

[10] Nuclear reprogramming of somatic cells after fusion with human embryonic stem cells [J].

Cowan, CA ;

Atienza, J ;

Melton, DA ;

Eggan, K .

SCIENCE, 2005, 309 (5739) :1369-1373

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