Palladium-Catalyzed C-H Bond Functionalization Reactions Using Phosphate/Sulfonate Hypervalent Iodine Reagents

被引：14

作者：

He, Yimiao ^{[1
]}

Huang, Lilan ^{[1
]}

Xie, Limei ^{[1
]}

Liu, Peng ^{[3
]}

Wei, Qiongmei ^{[2
]}

Mao, Fangfang ^{[1
]}

Zhang, Xuehong ^{[1
]}

Huang, Jun ^{[1
]}

Chen, Sijing ^{[1
]}

Huang, Chusheng ^{[1
]}

机构：

[1] Nanning Normal Univ, Coll Chem & Mat, Guangxi Key Lab Nat Polymer Chem & Phys, Nanning 530001, Peoples R China

[2] Nanning Normal Univ, Coll Tourism & Culture, Nanning 530001, Peoples R China

[3] Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, 190 Kaiyuan Ave, Guangzhou 510530, Guangdong, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 84卷 / 16期

基金：

中国国家自然科学基金;

关键词：

C(SP(3))-H BONDS; PROTECTING GROUP; SOLVENT-FREE; ACID; HYDROXYLATION; ALCOHOLS; DERIVATIVES; TOSYLATION; 8-METHYLQUINOLINES; ACYLOXYLATION;

D O I：

10.1021/acs.joc.9b01278

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new and operationally simple approach for palladium-catalyzed C-H functionalization reactions utilizing an organophosphorus/sulfonate hypervalent iodine reagent as both an oxidant and the source of a functional group has been developed. Through this method, the oxidative phosphorylation-, sulfonation-, and hydroxylation of unactivated benzyl C(sp(3))-H bonds, along with the hydroxylation and arylation of aryl C(sp(2))-H bonds, are successfully realized under mild conditions and with excellent site-selectivity. The versatile C-OSO2R bond provides a platform for a wide array of subsequent diversification reactions.

引用

页码：10088 / 10101

页数：14

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