Enantioselective cyanocarbonation of ketones with chiral base

被引：37
作者：
Tian, Shi-Kai [1 ]
Deng, Li [1 ]
机构：
[1] Brandeis Univ, Dept Chem, Waltham, MA 02454 USA
来源：
TETRAHEDRON | 2006年 / 62卷 / 49期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1016/j.tet.2006.06.077
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A highly enantioselective cyanocarbonation of dialkyl ketones catalyzed by commercially available and easily recyclable cinchona alkaloid derivatives has been developed. The reaction provides a useful approach for the enantioselective construction of tetrasubstituted carbon stereocenters. Mechanistic studies have been carried out to shed light on the origin of the catalytic activity of the cinchona alkaloid and the asymmetric induction step. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码：11320 / 11330
页数：11
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