Crystal structure of the co-crystalline adduct 4-((4,4-dimethyl-2,6-dioxocyclohexylidene) methylamino)-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide - acetic acid (1/1), C21H24N4O4S •C2H4O2

被引：2
作者：
Ghorab, Mostafa M. [3 ,4 ]
Alsaid, Mansour S. [3 ]
Al-Dosari, Mohmmed S. [3 ]
Ghabbour, Hazem A. [1 ,2 ]
机构：
[1] King Saud Univ, Coll Pharm, Dept Pharmaceut Chem, POB 2457, Riyadh 11451, Saudi Arabia
[2] Univ Mansoura, Fac Pharm, Dept Med Chem, Mansoura 35516, Egypt
[3] King Saud Univ, Coll Pharm, Dept Pharmacognosy, POB 2457, Riyadh 11451, Saudi Arabia
[4] Atom Energy Author, Natl Ctr Radiat Res & Technol, Dept Drug Radiat Res, POB 29, Cairo, Egypt
来源：
ZEITSCHRIFT FUR KRISTALLOGRAPHIE-NEW CRYSTAL STRUCTURES | 2017年 / 232卷 / 03期
关键词：
CARBONIC-ANHYDRASE; MOLECULAR DOCKING; SULFONAMIDE; INHIBITORS;
D O I：
10.1515/ncrs-2016-0295
中图分类号：
O7 [晶体学];
学科分类号：
0702 ; 070205 ; 0703 ; 080501 ;
摘要：
C23H28N4O6S, triclinic, P (1) over bar (no. 2), a= 7.3612(3) angstrom, b= 9.2370(4)angstrom, c= 19.2940(8) angstrom, alpha= 94.657(2)degrees, beta= 96.902(2)degrees, gamma= 113.010(2)degrees, V = 1186.92(9)angstrom(3), Z = 2, R-gt(F)= 0.0617, wR(ref)(F-2)= 0.1575, T = 100 K.
引用
收藏
页码：417 / 419
页数：3
相关论文
共 15 条
  • [1] Synthesis and anticancer activity of some novel trifluoromethylquinolines carrying a biologically active benzenesulfonamide moiety
    Al-Dosari, Mohammed S.
    Ghorab, Mostafa M.
    Al Said, Mansour S.
    Nissan, Yassin M.
    Ahmed, Abdulkareem B.
    [J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2013, 69 : 373 - 383
  • [2] [Anonymous], 1999, Pharmaceutical Substances
  • [3] Design, synthesis and molecular docking of novel N,N-dimethylbenzenesulfonamide derivatives as potential antiproliferative agents
    Bashandy, Mahmoud S.
    Alsaid, Mansour S.
    Arafa, Reem K.
    Ghorab, Mostafa M.
    [J]. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2014, 29 (05) : 619 - 627
  • [4] Brucker, 2009, SAINT SADABS
  • [5] Antiprotozoal and cytotoxicity evaluation of sulfonamide and urea analogues of quinacrine
    Chibale, K
    Haupt, H
    Kendrick, H
    Yardley, V
    Saravanamuthu, A
    Fairlamb, AH
    Croft, SL
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2001, 11 (19) : 2655 - 2657
  • [6] Sulfonamide-1,2,4-triazole derivatives as antifungal and antibacterial agents: Synthesis, biological evaluation, lipophilicity, and conformational studies
    Ezabadi, Raj Rahavi
    Camoutsis, Charalabos
    Zoumpoulakis, Panagiotis
    Geronikaki, Athina
    Sokovic, Marina
    Glamocilija, Jasmina
    Ciric, Ana
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY, 2008, 16 (03) : 1150 - 1161
  • [7] Gal CSL, 2001, CARDIOVASC DRUG REV, V19, P201
  • [8] Carbonic anhydrase inhibitors: Synthesis, molecular docking, cytotoxic and inhibition of the human carbonic anhydrase isoforms I, II, IX, XII with novel benzenesulfonamides incorporating pyrrole, pyrrolopyrimidine and fused pyrrolopyrimidine moieties
    Ghorab, Mostafa M.
    Alsaid, Mansour S.
    Ceruso, Mariangela
    Nissan, Yassin M.
    Supuran, Claudiu T.
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY, 2014, 22 (14) : 3684 - 3695
  • [9] Hansch C., 1990, COMPREHENSIVE MED CH, V2
  • [10] Synthesis and structure-activity relationships of potent and orally active sulfonamide ETB selective antagonists
    Kanda, Y
    Kawanishi, Y
    Oda, K
    Sakata, T
    Mihara, S
    Asakura, K
    Kanemasa, T
    Ninomiya, M
    Fujimoto, M
    Konoike, T
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY, 2001, 9 (04) : 897 - 907
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