Therapeutic potential of lefamulin in the treatment of community-acquired pneumonia

被引：10

作者：

Perry, Whitney ^{[1
]}

Golan, Yoav ^{[1
]}

机构：

[1] Tufts Med Ctr, Div Geog Med & Infect Dis, Boston, MA 02111 USA

来源：

FUTURE MICROBIOLOGY | 2019年 / 14卷 / 11期

关键词：

community acquired; lefamulin; pneumonia; PLEUROMUTILIN ANTIBIOTIC BC-3781; ACUTE BACTERIAL SKIN; ANTIMICROBIAL ACTIVITY; DERIVATIVES; RESISTANCE; COMPOUND;

D O I：

10.2217/fmb-2019-0027

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Despite the increasing availability of antibiotics with activity against pathogens that cause community-acquired pneumonia (CAP), CAP remains a major cause of morbidity, hospital admissions and readmissions, and mortality. Lefamulin is a novel pleuromutilin antibiotic with potent in vitro activity against both typical and atypical CAP pathogens. In this review of the medical literature, we summarize the available information, including mounting clinical evidence, about lefamulin and its potential value in CAP.

引用

页码：927 / 939

页数：13

共 29 条

[1]

Alexander E., 2018, OPEN FORUM INFECT S1, V5, pS761, DOI [10.1093/ofid/ofy229.2180, DOI 10.1093/OFID/OFY229.2180]

[2]

[Anonymous], 2018, NABRIVA THERAPEUTICS

[3]

Bennett JE, 2015, MANDELL DOUGLAS BENN, P358

[4]

Bhavani S, 2016, ID WEEK LA US 26 30

[5]

Cox HL, 2015, MANDELL DOUGLAS BENN, P406

[6]

Craig WA, 2010, 28 EUR C CLIN MICR I

[7] A novel pleuromutilin antibacterial compound, its binding mode and selectivity mechanism [J].

Eyal, Zohar ;

Matzov, Donna ;

Krupkin, Miri ;

Paukner, Susanne ;

Riedl, Rosemarie ;

Rozenberg, Haim ;

Zimmerman, Ella ;

Bashan, Anat ;

Yonath, Ada .

SCIENTIFIC REPORTS, 2016, 6

[8]

File T, 2018, 28 EUR C CLIN MICR I

[9] Efficacy and Safety of Intravenous-to-oral Lefamulin, a Pleuromutilin Antibiotic, for the Treatment of Community-acquired Bacterial Pneumonia: The Phase III Lefamulin Evaluation Against Pneumonia (LEAP 1) Trial [J].

File, Thomas M., Jr. ;

Goldberg, Lisa ;

Das, Anita ;

Sweeney, Carolyn ;

Saviski, John ;

Gelone, Steven P. ;

Seltzer, Elyse ;

Paukner, Susanne ;

Wicha, Wolfgang W. ;

Talbot, George H. ;

Gasink, Leanne B. .

CLINICAL INFECTIOUS DISEASES, 2019, 69 (11) :1856-1867

[10] Interaction of pleuromutilin derivatives with the ribosomal peptidyl transferase center [J].

Long, KS ;

Hansen, LH ;

Jakobsen, L ;

Vester, B .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2006, 50 (04) :1458-1462

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