Risk factors for mortality in patients undergoing peritoneal dialysis: a systematic review and meta-analysis

被引：45
作者：
Zhang, Jialing [1 ]
Lu, Xiangxue [1 ]
Li, Han [1 ]
Wang, Shixiang [1 ]
机构：
[1] Capital Med Univ, Beijing Chao Yang Hosp, Dept Blood Purificat, 8 Gongti South Rd, Beijing 100020, Peoples R China
来源：
RENAL FAILURE | 2021年 / 43卷 / 01期
基金：
中国国家自然科学基金; 北京市自然科学基金;
关键词：
Cardiovascular mortality; meta-analysis; mortality; peritoneal dialysis; risk factor; BODY-MASS INDEX; EARLY-ONSET PERITONITIS; RESIDUAL RENAL-FUNCTION; C-REACTIVE PROTEIN; ALKALINE-PHOSPHATASE; CARDIOVASCULAR-DISEASE; TECHNIQUE FAILURE; GLYCEMIC CONTROL; URIC-ACID; SURVIVAL;
D O I：
10.1080/0886022X.2021.1918558
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Aim Inconsistent investigations of the risk factors for all-cause mortality in patients undergoing peritoneal dialysis (PD) were reported. The present meta-analysis aimed to assess the impact of some clinical characteristics on the risk of mortality in PD patients. Methods: PubMed and Embase were systematically searched for studies evaluating the risk factors for all-cause mortality in PD patients. Hazard ratio (HR) and 95% confidence interval (CI) were derived using a random-effect or fixed-effect model considering the heterogeneity across studies. Result: A total of 26 studies were included in this meta-analysis in accordance with the inclusion and exclusion criteria. Age, primary cardiovascular diseases, diabetes mellitus, and high level of alkaline phosphatase showed significant positive associations with elevated risk of all-cause and cardiovascular mortality in PD patients, while hemoglobin acted as a benefit factor. Furthermore, early onset of peritonitis, high peritoneal transport status, elevated body mass index and high-sensitivity C-reactive protein could also considerably increase the risk of all-cause mortality. The absolute serum level of magnesium, potassium, and uric acid required to improve survival in PD patients should be verified further. Conclusions: Multiple factors could affect the risk of mortality in PD patients.
引用
收藏
页码：743 / 753
页数：11
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