Autophagy Promotes Memory Formation

被引：8

作者：

Tripathi, Timir ^{[1
]}

Kalita, Parismita ^{[1
]}

Martins, Ralph ^{[2
,3
]}

Bharadwaj, Prashant ^{[2
,4
]}

机构：

[1] NE Hill Univ, Dept Biochem, Mol & Struct Biophys Lab, Shillong 793022, Meghalaya, India

[2] Edith Cowan Univ, Sch Med & Hlth Sci, Ctr Excellence Alzheimers Dis Res & Care, Joondalup, WA 6027, Australia

[3] Macquarie Univ, Sch Biomed Sci, Sydney, NSW 2109, Australia

[4] Curtin Univ, CHIRI, Sch Pharm & Biomed Sci, Fac Hlth Sci, Bentley, WA 6102, Australia

来源：

ACS CHEMICAL NEUROSCIENCE | 2019年 / 10卷 / 08期

关键词：

Autophagy; autophagosome; hippocampus; aging; synaptic plasticity; neurodegeneration; memory;

D O I：

10.1021/acschemneuro.9b00317

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Autophagy is traditionally known to be a stress response and a quality control mechanism for protecting cells from injury and disease. In addition to its housekeeping functions, autophagy also has specialized functions including regulation of synaptic activity and neurotransmission. Decreased autophagy is commonly associated with aging; however, the functional importance of autophagy in regulating cognitive function and its decline during aging were previously not known. A recent study showed that the induction of hippocampal autophagy improves cognition by enhancing memory formation and reverses memory decline during aging. Here, we discuss the findings of that study and explore the scope of the physiological process of autophagy in the development of treatments for age-related cognitive decline and neurodegenerative diseases.

引用

页码：3337 / 3339

页数：5

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