Efficient Continuous-Flow Synthesis and Evaluation of Anticancer Activity of Novel Quinoline-Pyrazoline Derivatives

被引：3
|
作者：
Kumar, K. Santhosh [1 ,2 ]
Siddaiah, V. [2 ]
Lilakar, J. D. [1 ]
Sunanda, K. [3 ]
Ganesh, A. [4 ]
机构：
[1] Dr Reddys Labs, Proc Res & Dev, Bollaram 502325, Medak, India
[2] Andhra Univ, Dept Organ Chem & FDW, Visakhapatnam 530003, Andhra Pradesh, India
[3] Andhra Univ, Dept Microbiol, Visakhapatnam 530003, Andhra Pradesh, India
[4] Orbit Chem Pharmaceut Private, Hyderabad 500051, India
来源：
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2020年 / 56卷 / 11期
关键词：
continuous-flow synthesis; Claisen-Schmidt condensation; Michael addition reaction; pyrazoline; quinoline; anticancer activity; MICROWAVE-ASSISTED SYNTHESIS; SOLVENT-FREE; ONE-POT; 2-PYRAZOLINES;
D O I：
10.1134/S1070428020110160
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient and simple continuous-flow synthetic protocol for novel quinoline-tethered pyrazoline derivatives, which involves condensation of 2-chloroquinoline-3-carbaldehydewith arylmethyl ketones followed by cyclisation with phenyl hydrazine, was developed. The newly synthesized pyrazolines were characterized by IR, H-1 and C-13 NMR spectroscopy, mass spectrometry, and elemental analysis and tested for anticancer activity against A375 (melanoma), MCF7 (breast), and HT-29 (colon) cell lines. Some of the newly synthesized derivatives showed a higher activity than the control drug Doxorubicin.
引用
收藏
页码：2014 / 2021
页数：8
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