Efficient Continuous-Flow Synthesis and Evaluation of Anticancer Activity of Novel Quinoline-Pyrazoline Derivatives

被引：3

作者：

Kumar, K. Santhosh ^{[1
,2
]}

Siddaiah, V. ^{[2
]}

Lilakar, J. D. ^{[1
]}

Sunanda, K. ^{[3
]}

Ganesh, A. ^{[4
]}

机构：

[1] Dr Reddys Labs, Proc Res & Dev, Bollaram 502325, Medak, India

[2] Andhra Univ, Dept Organ Chem & FDW, Visakhapatnam 530003, Andhra Pradesh, India

[3] Andhra Univ, Dept Microbiol, Visakhapatnam 530003, Andhra Pradesh, India

[4] Orbit Chem Pharmaceut Private, Hyderabad 500051, India

来源：

RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2020年 / 56卷 / 11期

关键词：

continuous-flow synthesis; Claisen-Schmidt condensation; Michael addition reaction; pyrazoline; quinoline; anticancer activity; MICROWAVE-ASSISTED SYNTHESIS; SOLVENT-FREE; ONE-POT; 2-PYRAZOLINES;

D O I：

10.1134/S1070428020110160

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and simple continuous-flow synthetic protocol for novel quinoline-tethered pyrazoline derivatives, which involves condensation of 2-chloroquinoline-3-carbaldehydewith arylmethyl ketones followed by cyclisation with phenyl hydrazine, was developed. The newly synthesized pyrazolines were characterized by IR, H-1 and C-13 NMR spectroscopy, mass spectrometry, and elemental analysis and tested for anticancer activity against A375 (melanoma), MCF7 (breast), and HT-29 (colon) cell lines. Some of the newly synthesized derivatives showed a higher activity than the control drug Doxorubicin.

引用

页码：2014 / 2021

页数：8

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