Phosphodiesterase type 5 inhibitor to riociguat transition is associated with hemodynamic and symptomatic improvement in pulmonary hypertension

被引：9
作者：
Davey, Ryan [1 ]
Benza, Raymond L. [2 ]
Murali, Srinivas [2 ]
Raina, Amresh [2 ]
机构：
[1] Western Univ, Div Cardiol, London, ON, Canada
[2] Allegheny Gen Hosp, Cardiovasc Inst, Pittsburgh, PA 15212 USA
来源：
PULMONARY CIRCULATION | 2017年 / 7卷 / 02期
关键词：
hemodynamics; pulmonary arterial hypertension; rioicguat; transition; ARTERIAL-HYPERTENSION; SILDENAFIL; MANAGEMENT;
D O I：
10.1177/2045893217708566
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Riociguat is a soluble guanylate cyclase stimulator approved for the treatment of pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension. We studied the clinical and hemodynamics effects of transitioning 12 pulmonary hypertension patients from Phosphodiesterase type 5 inhibitor (PDE5i) to riociguat, and demonstrated a significant increase in cardiac index, fall in pulmonary vascular resistance, and improvement in functional class with this switch. Switch from PDE5i to riociguat appeared to be safe and fairly well tolerated in most patients.
引用
收藏
页码：539 / 542
页数：4
相关论文
共 12 条
[1]   Management of pulmonary arterial hypertension with a focus on combination therapies [J].
Benza, Raymond L. ;
Park, Myung H. ;
Keogh, Anne ;
Girgis, Reda E. .
JOURNAL OF HEART AND LUNG TRANSPLANTATION, 2007, 26 (05) :437-446
[2]   2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension The Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS) Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC), International Society for Heart and Lung Transplantation (ISHLT) [J].
Galie, Nazzareno ;
Humbert, Marc ;
Vachiery, Jean-Luc ;
Gibbs, Simon ;
Lang, Irene ;
Torbicki, Adam ;
Simonneau, Gerald ;
Peacock, Andrew ;
Noordegraaf, Anton Vonk ;
Beghetti, Maurice ;
Ghofrani, Ardeschir ;
Gomez Sanchez, Miguel Angel ;
Hansmann, Georg ;
Klepetko, Walter ;
Lancellotti, Patrizio ;
Matucci, Marco ;
McDonagh, Theresa ;
Pierard, Luc A. ;
Trindade, Pedro T. ;
Zompatori, Maurizio ;
Hoeper, Marius .
EUROPEAN HEART JOURNAL, 2016, 37 (01) :67-+
[3]   PATENT PLUS: a blinded, randomised and extension study of riociguat plus sildenafil in pulmonary arterial hypertension [J].
Galie, Nazzareno ;
Mueller, Katharina ;
Scalise, Andrea-Viviana ;
Gruenig, Ekkehard .
EUROPEAN RESPIRATORY JOURNAL, 2015, 45 (05) :1314-1322
[4]   Riociguat: Mode of Action and Clinical Development in Pulmonary Hypertension [J].
Ghofrani, Hossein-Ardeschir ;
Humbert, Marc ;
Langleben, David ;
Schermuly, Ralph ;
Stasch, Johannes-Peter ;
Wilkins, Martin R. ;
Klinger, James R. .
CHEST, 2017, 151 (02) :468-480
[5]   Riociguat for the Treatment of Pulmonary Arterial Hypertension [J].
Ghofrani, Hossein-Ardeschir ;
Galie, Nazzareno ;
Grimminger, Friedrich ;
Gruenig, Ekkehard ;
Humbert, Marc ;
Jing, Zhi-Cheng ;
Keogh, Anne M. ;
Langleben, David ;
Kilama, Michael Ochan ;
Fritsch, Arno ;
Neuser, Dieter ;
Rubin, Lewis J. .
NEW ENGLAND JOURNAL OF MEDICINE, 2013, 369 (04) :330-340
[6]   Riociguat for the Treatment of Chronic Thromboembolic Pulmonary Hypertension [J].
Ghofrani, Hossein-Ardeschir ;
D'Armini, Andrea M. ;
Grimminger, Friedrich ;
Hoeper, Marius M. ;
Jansa, Pavel ;
Kim, Nick H. ;
Mayer, Eckhard ;
Simonneau, Gerald ;
Wilkins, Martin R. ;
Fritsch, Arno ;
Neuser, Dieter ;
Weimann, Gerrit ;
Wang, Chen .
NEW ENGLAND JOURNAL OF MEDICINE, 2013, 369 (04) :319-329
[7]   Rationale and study design of RESPITE: An open-label, phase 3b study of riociguat in patients with pulmonary arterial hypertension who demonstrate an insufficient response to treatment with phosphodiesterase-5 inhibitors [J].
Hoeper, Marius M. ;
Klinger, James R. ;
Benza, Raymond L. ;
Simonneau, Gerald ;
Langleben, David ;
Naeije, Robert ;
Corris, Paul A. .
RESPIRATORY MEDICINE, 2017, 122 :S18-S22
[8]   Management of Pulmonary Arterial Hypertension [J].
McLaughlin, Vallerie V. ;
Shah, Sanjiv J. ;
Souza, Rogerio ;
Humbert, Marc .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2015, 65 (18) :1976-1997
[9]   Nitric oxide-independent stimulation of soluble guanylate cyclase reduces organ damage in experimental low-renin and high-renin models [J].
Sharkovska, Yuliya ;
Kalk, Philipp ;
Lawrenz, Bettina ;
Godes, Michael ;
Hoffmann, Linda Sarah ;
Wellkisch, Kathrin ;
Geschka, Sandra ;
Relle, Katharina ;
Hocher, Berthold ;
Stasch, Johannes-Peter .
JOURNAL OF HYPERTENSION, 2010, 28 (08) :1666-1675
[10]   Long-term use of sildenafil in inoperable chronic thromboembolic pulmonary hypertension [J].
Suntharalingam, Jay ;
Treacy, Carinei M. ;
Doughty, Natalie J. ;
Goldsmith, Kimberley ;
Soon, Elaine ;
Toshner, Mark R. ;
Sheares, Karen K. ;
Hughes, Rodney ;
Morrell, Nicholas W. ;
Pepke-Zaba, Joanna .
CHEST, 2008, 134 (02) :229-236
12