Fusion pacing in patients with right bundle branch block who undergo cardiac resynchronization therapy

Purpose: Patients with right bundle branch block (RBBB) are less likely to respond to cardiac resynchronization therapy (CRT). We aimed to assess whether patients with RBBB respond to CRT with biventricular fusion pacing. Methods: Consecutive patients with RBBB at a single tertiary care center, who were implanted with a CRT device capable of biventricular fusion pacing using SyncAV programming, were assessed and compared to a historical cohort of CRT patients with RBBB. QRSd was measured and compared during intrinsic conduction, nominal CRT pacing and manual electrocardiogram-based optimized SyncAV programming. Left ventricular ejection fraction (LVEF) was also compared before and 6 months after CRT. Results: We included 8 consecutive patients with RBBB (group 1) who were able to undergo SyncAV programming and 16 patients with RBBB (group 2) from a historical cohort. In group 1, compared to mean intrinsic conduction QRSd (155 +/- 13 ms), mean nominally-paced QRSd was 156 +/- 15 ms (Delta QRSd 1.3 +/- 11.6; p = 0.77) and SyncAV-optimized paced QRSd was 135 +/- 14 ms (Delta QRSd -20.0 +/- 20.4; p = 0.03 and Delta QRSd -21.3 +/- 16.3; p = 0.008; compared to intrinsic conduction and nominal pacing respectively). In group 2, mean QRSd with nominal pacing was 160 +/- 24 ms (Delta QRSd 3.8 +/- 33.4; p = 0.66 compared to intrinsic conduction). In group 1, baseline LVEF was 22.1 +/- 11.5 and after 6 months of follow-up was 27.8 +/- 8.6 (p = 0.047). In group 2, the baseline LVEF was 27.2 +/- 10.6 and after 6 months of follow-up was 25.0 +/- 10.0 (p = 0.45). Conclusions: CRT programed to allow biventricular fusion pacing significantly improved electrical synchrony and LVEF in patients with RBBB. Larger studies are required to confirm these findings. (C) 2020 Elsevier Inc. All rights reserved.