(S)-(-)-α,α-Di(2-naphthyl)-2-pyrrolidinemethanol, a useful tool to study the recognition mechanism in chiral ligand-exchange chromatography

被引：16

作者：

Natalini, Benedetto ^{[1
]}

Sardella, Roccaldo ^{[1
]}

Macchiarulo, Antonio ^{[1
]}

Natalini, Serena ^{[1
]}

Pellicciari, Roberto ^{[1
]}

机构：

[1] Univ Perugia, Dipartimento Chim & Tecnol Farm, I-06123 Perugia, Italy

来源：

JOURNAL OF SEPARATION SCIENCE | 2007年 / 30卷 / 01期

关键词：

chiral stationary phase; classification structure-property relationship; dynamic coating; enantioselective separation; ligand-exchange;

D O I：

10.1002/jssc.200600242

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A dynamic coating of the RP-18 carbon chain layers with the new chiral selector (S)(-)-alpha,alpha-di(2-naphthyl)-2-pyrrolidinemethanol allowed the formation of a mixed chiral stationary phase that has been used in the separation of a selected set of amino acid racemates. Both a representative model and classification structure-property relationship studies have been performed in order to study the contribution of hydrophobic, bulky and electron-donating groups in the side chain of the chiral selector to the mechanism of chiral recognition.

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页码：21 / 27

页数：7

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